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© 2018

The Adenosine Receptors

  • Pier Andrea Borea
  • Katia Varani
  • Stefania Gessi
  • Stefania Merighi
  • Fabrizio Vincenzi
Book

Part of the The Receptors book series (REC, volume 34)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Stefania Gessi, Stefania Merighi, Katia Varani
    Pages 1-11
  3. Detlev Boison
    Pages 13-32
  4. Stefania Merighi, Stefania Gessi, Pier Andrea Borea
    Pages 33-57
  5. Zhan-Guo Gao, Dilip K. Tosh, Shanu Jain, Jinha Yu, Rama R. Suresh, Kenneth A. Jacobson
    Pages 59-89
  6. Stefania Baraldi, Pier Giovanni Baraldi, Paola Oliva, Kiran S. Toti, Antonella Ciancetta, Kenneth A. Jacobson
    Pages 91-136
  7. Christa E. Müller, Younis Baqi, Sonja Hinz, Vigneshwaran Namasivayam
    Pages 137-168
  8. Kenneth A. Jacobson, Dilip K. Tosh, Zhan-Guo Gao, Jinha Yu, Rama R. Suresh, Harsha Rao et al.
    Pages 169-198
  9. Fabrizio Vincenzi, Katia Varani, Pier Andrea Borea
    Pages 199-215
  10. Antonella Ferrante, Roberta De Simone, Maria Antonietta Ajmone-Cat, Luisa Minghetti, Patrizia Popoli
    Pages 217-237
  11. Paula M. Canas, Rodrigo A. Cunha, Paula Agostinho
    Pages 259-280
  12. David Blum, En Chiang Chern, Maria Rosaria Domenici, Luc Buée, Ching Yeh Lin, Sergi Ferré et al.
    Pages 281-308
  13. Diogo Miguel Rombo, Joaquim Alexandre Ribeiro, Ana Maria Sebastião
    Pages 309-350
  14. Felicita Pedata, Ilaria Dettori, Lisa Gaviano, Elisabetta Coppi, Anna Maria Pugliese
    Pages 351-378
  15. Daniela Salvemini, Timothy M. Doyle, Tally M. Largent-Milnes, Todd W. Vanderah
    Pages 413-437
  16. Julia Hesse, Christina Alter, Jürgen Schrader
    Pages 439-460
  17. Amir Pelleg, Riccardo Polosa
    Pages 461-470
  18. H. Thomas Lee, Jurgen Schnermann
    Pages 471-498

About this book

Introduction

This book traces the history of adenosine receptor research from molecular biology to medicinal chemistry to behavior, including their implications in disease and potential strategies as therapeutic targets. It provides the reader with a comprehensive overview of the adenosine receptors that includes information on all subtypes - A1, A2A, A2B and A3. Aspects addressed include the most up to date information on their functional distribution in the nervous and peripheral systems, behavioral roles in inflammation, cancer, pain and neurological diseases such as Huntington’s disease, Epilepsy, Parkinson’s disease and Alzheimer’s disease.

Keywords

molecular structure receptor subtypes research drug and development biological functions adenosine based pharmacotherapy diseases

Editors and affiliations

  • Pier Andrea Borea
    • 1
  • Katia Varani
    • 2
  • Stefania Gessi
    • 3
  • Stefania Merighi
    • 4
  • Fabrizio Vincenzi
    • 5
  1. 1.Department of Medical SciencesUniversity of FerraraFerraraItaly
  2. 2.Department of Medical SciencesUniversity of FerraraFerraraItaly
  3. 3.Department of Medical SciencesUniversity of FerraraFerraraItaly
  4. 4.Department of Medical SciencesUniversity of FerraraFerraraItaly
  5. 5.Department of Medical SciencesUniversity of FerraraFerraraItaly

About the editors

Pier Andrea Borea received his degree in Chemistry Summa cum Laude from the University of Ferrara in 1967. He moved as Visiting Professor to Preclinical Research Department, Sandoz, Basel (CH) and to Medical Research Council Molecular Neurobiology Unit, Cambridge (UK). At present he is Honorary Professor of Pharmacology and member of the Board of Directors at the University of Ferrara. He is member of the Italian Society of Pharmacology and Purine Club. He has published 400 publications in international journals and contributed about 20 chapters to International Books. He has participated in more than 200 congresses, presenting main, oral and poster communications. He is also named as inventor in about 20 Patents. He has been invited to give about 50 Plenary Lectures at International Symposia and at several Universities. His main field of interest is represented by the study, at the molecular level, of drug-receptor interactions and in particular of the P1 adenosine receptor system.

Katia Varani received her degree in Biology in 1988 and her Ph.D. in Cellular and Molecular Pharmacology in 1995 from the University of Ferrara. She is currently Associate Professor of Pharmacology at the Medical Sciences Department of the University of Ferrara. Her research activity mainly involve pharmacological, biochemical and molecular characterization of adenosine receptors in human neurodegenerative diseases, chronic and neuropathic pain, inflammatory diseases and cancer.  She has published 250 publications on peer-reviewed international scientific journals, 15 book chapters and several communications in international and national congresses. She is member of the Italian Society of Pharmacology and Purine Club.

Stefania Gessi received her degree in Biology Summa cum Laude from University of Ferrara in 1994 and her Ph.D. in Cellular and Molecular Pharmacology in 2000 under the guidance of Professor Pier Andrea Borea. She moved at Centro Ricerche Schering-Plough, Parco Scientifico San Raffaele (Milano) and at the Department of Physiology and Pharmacology, section of Molecular Neuropharmacology, Karolinska Institutet (Stockholm). She is currently Associate Professor of Pharmacology in the Medical Sciences Department of the University of Ferrara. Her research activity focused mainly on the pharmacological, biochemical and molecular study of adenosine receptors in inflammation and cancer and is documented by more than 130 publications on peer-reviewed international scientific journals, 18 book chapters and several communications in international and national congresses. She is member of the Italian Society of Pharmacology and Purine Club.

Stefania Merighi received her degree in Biology Summa cum Laude at the University of Ferrara (Italy) in 1997 and obtained her Ph.D. in Cellular and Molecular Pharmacology at the same University in 2003. Currently, she is Associate Professor of Pharmacology at the University of Ferrara, a position she has held since 2017. Her research activities primarily focus on the pharmacological, biochemical and molecular study of GPCRs in oncology and neuroinflammation and has published extensively in this area. Her research activity is documented by more than 100 publications on peer-reviewed International scientific journals and several communications in International and National congresses. She is member of the Italian Society of Pharmacology and Purine Club.

Fabrizio Vincenzi received his degree in Biology from University of Ferrara in 2004 and obtained his Ph.D. in Cellular and Molecular Pharmacology in 2008 at the section of Pharmacology of the University of Ferrara. His main research field is represented by the study of the drug-receptor interaction with specific interest in the thermodynamic and kinetic aspect of the ligand-receptor binding. He primarily focused his research on the study of G-protein coupled receptors and in particular on adenosine receptors and their involvement in neurodegenerative diseases, pain, chronic inflammatory diseases, anxiety and cancer. He has published 80 scientific papers in peer-reviewed international journals and is member of the Italian Society of Pharmacology and Purine Club.

Bibliographic information

  • Book Title The Adenosine Receptors
  • Editors Pier Andrea Borea
    Katia Varani
    Stefania Gessi
    Stefania Merighi
    Fabrizio Vincenzi
  • Series Title The Receptors
  • Series Abbreviated Title The Receptors
  • DOI https://doi.org/10.1007/978-3-319-90808-3
  • Copyright Information Springer Nature Switzerland AG 2018
  • Publisher Name Humana Press, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-90807-6
  • Softcover ISBN 978-3-030-08106-5
  • eBook ISBN 978-3-319-90808-3
  • Series ISSN 1048-6909
  • Series E-ISSN 2524-6488
  • Edition Number 1
  • Number of Pages XX, 593
  • Number of Illustrations 42 b/w illustrations, 29 illustrations in colour
  • Topics Neurochemistry
  • Buy this book on publisher's site
Industry Sectors
Biomedicine
Biotechnology