Voltage-gated Sodium Channels: Structure, Function and Channelopathies

  • Mohamed Chahine

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 246)

Table of contents

  1. Front Matter
    Pages i-x
  2. Evolution of Voltage-Gated Sodium Channels

    1. Front Matter
      Pages 1-1
    2. Atsuo Nishino, Yasushi Okamura
      Pages 3-32
    3. Steven Molinarolo, Daniele Granata, Vincenzo Carnevale, Christopher A. Ahern
      Pages 33-49
  3. The Structural Basis of Sodium Channel Function

    1. Front Matter
      Pages 51-51
    2. Tamer M. Gamal El-Din, Michael J. Lenaeus, William A. Catterall
      Pages 53-72
    3. Elise Balse, Catherine Eichel
      Pages 73-99
    4. Zifan Pei, Yanling Pan, Theodore R. Cummins
      Pages 101-124
    5. A. Mercier, P. Bois, A. Chatelier
      Pages 125-145
    6. Colin H. Peters, Mohammad-Reza Ghovanloo, Cynthia Gershome, Peter C. Ruben
      Pages 147-160
    7. Ademuyiwa S. Aromolaran, Mohamed Chahine, Mohamed Boutjdir
      Pages 161-184
  4. Drugs and Toxins Interactions with Sodium Channels

    1. Front Matter
      Pages 185-185
    2. M. E. O’Leary, M. Chahine
      Pages 209-231
    3. Alessandro Farinato, Concetta Altamura, Jean-François Desaphy
      Pages 233-250
  5. Pathophysiology of Sodium Channels

    1. Front Matter
      Pages 307-307
    2. Stephen C. Cannon
      Pages 309-330
    3. Eleonora Savio-Galimberti, Mariana Argenziano, Charles Antzelevitch
      Pages 331-354
    4. Katrin Schrenk-Siemens, Corinna Rösseler, Angelika Lampert
      Pages 355-369
    5. J. R. Groome, A. Moreau, L. Delemotte
      Pages 371-399
    6. Bela Joos, Benjamin M. Barlow, Catherine E. Morris
      Pages 401-422
    7. Alexandra A. Bouza, Lori L. Isom
      Pages 423-450

About this book


This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.


voltage-gated sodiium channels Biophysics Channelopathies Electrophysiology Pharmacology

Editors and affiliations

  • Mohamed Chahine
    • 1
  1. 1.CERVO Brain Research CenterInstitut Universitaire en Santé MentaleQuebecCanada

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