Rapid-Eye-Movement Sleep Behavior Disorder

  • Carlos H. Schenck
  • Birgit Högl
  • Aleksandar Videnovic

Table of contents

  1. Front Matter
    Pages i-xx
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Carlos H. Schenck
      Pages 3-8
    3. Carlos H. Schenck
      Pages 9-18
    4. Wolfgang Oertel, Geert Mayer, Aaro V. Salminen, Carlos H. Schenck
      Pages 19-30
  3. RBD: Clinical Spectrum

    1. Front Matter
      Pages 31-31
    2. Laura Pérez-Carbonell, Alex Iranzo
      Pages 33-52
    3. Luigi Ferini-Strambi, Francesca Marta Casoni, Marco Zucconi
      Pages 77-91
    4. Stuart J. McCarter, Erik K. St. Louis
      Pages 107-121
    5. Siu Ping Lam, Jihui Zhang, Shirley Xin Li, Yun Kwok Wing
      Pages 123-134
    6. Giuseppe Plazzi
      Pages 135-151
    7. Federica Provini, Naoko Tachibana
      Pages 153-171
    8. Edgar Garcia-Rill, Carlos H. Schenck
      Pages 173-186
    9. Garima Shukla, Suresh Kotagal, Carlos H. Schenck
      Pages 187-200
    10. Yo-El S. Ju
      Pages 201-214
    11. Cynthia L. Bodkin
      Pages 215-222
    12. Isabelle Arnulf
      Pages 223-242
  4. Diagnosis and Treatment

    1. Front Matter
      Pages 243-243
    2. Ambra Stefani, Birgit Frauscher, Birgit Högl
      Pages 245-254
    3. Shirley Xin Li, Siu Ping Lam, Jihui Zhang, Yun Kwok Wing
      Pages 255-269
    4. Valérie Cochen De Cock
      Pages 281-289
    5. Michael J. Howell
      Pages 305-314
    6. Dieter Kunz, Frederik Bes
      Pages 315-331
    7. Carlos H. Schenck, Michael J. Howell
      Pages 333-345
    8. Raffaele Manni, Michele Terzaghi
      Pages 347-358
    9. Carlos H. Schenck, Michael J. Howell
      Pages 359-369
    10. Elena Antelmi, Giuseppe Plazzi
      Pages 371-386
  5. Clinical Research and Issues in RBD

    1. Front Matter
      Pages 387-387
    2. Paola Proserpio, Michele Terzaghi, Lino Nobili
      Pages 389-401
    3. Rosalie V. Kogan, Sanne K. Meles, Klaus L. Leenders, Kathrin Reetz, Wolfgang H. O. Oertel
      Pages 403-445
    4. Monica Puligheddu, Patrizia Congiu, Raffaele Ferri
      Pages 447-464
    5. Yuichi Inoue, Taeko Sasai-Sakuma
      Pages 465-474
    6. Masayuki Miyamoto, Tomoyuki Miyamoto, Koichi Hirata
      Pages 475-489
    7. Jean-François Gagnon, Pierre-Alexandre Bourgouin, Jessie De Roy, Daphné Génier Marchand
      Pages 491-507
    8. Marcus M. Unger, Wolfgang H. Oertel
      Pages 541-545
    9. Colum D. MacKinnon, Laila Alibiglou, Aleksandar Videnovic
      Pages 547-556
  6. RBD: Basic Science

    1. Front Matter
      Pages 557-557
    2. Carlos H. Schenck
      Pages 579-587
    3. Ziv Gan-Or, Guy A. Rouleau
      Pages 589-609
    4. Yuan-Yang Lai, Kung-Chiao Hsieh, Jerome M. Siegel
      Pages 611-623
  7. Challenges and Opportunities

    1. Front Matter
      Pages 639-639

About this book


This book describes a sleep disorder belonging to the category of parasomnias (i.e. the sleep behavioral and experiential disorders) characterized by abnormal vocal and motor behaviors in the context of vivid dreams and loss of the customary muscle atonia during the stage of sleep called REM sleep. REM-atonia - one of the defining features of REM sleep, along with rapid-eye-movements and a highly activated brain state - serves a protective function, preventing the dreamer from acting-out dreams and becoming injured. REM sleep behavior disorder (RBD) was first described in 1986 by Schenck and colleagues; since then the understanding of the condition has increased exponentially, also pointing out its strong association with the development of neurodegenerative disorders characterized by alpha synuclein deposition, such as Parkinson’s disease, Dementia with Lewy bodies, and Multiple System Atrophy. Furthermore, RBD is now considered one of the earliest markers of ongoing alpha synuclein neurodegeneration, and provides a window of opportunity for testing disease modifying therapies that may slow down or halt the progression of these disorders for which there is currently no cure.

Additionally, RBD is today known to be present in more than 50% of patients with narcolepsy-cataplexy, and can also be triggered by the most commonly prescribed antidepressant medications (e.g. SSRIs, venlafaxine). RBD has been documented as occurring, with variable frequency, with virtually every category of neurologic disease and has also helped expand the field of dream research.

The volume Editors have pioneered scientific and clinical advances in the field and, partnering with leading sleep clinicians and researchers on this book, have produced an invaluable guide to specialists in sleep medicine, neurology, psychiatry and psychology. There are also strong contributions in this book by leading basic science researchers, and so this book should also appeal to neuroscientists. As stated in the book, "RBD is situated at a strategic and busy crossroads of sleep medicine and the neurosciences. RBD offers great breadth and depth of research opportunities, including extensive inter-disciplinary and multinational research opportunities...RBD is an 'experiment of Nature' in which knowledge from the study of motor-behavioral dyscontrol during REM sleep, with dream-enactment, has cast a broad and powerful light on a multitude of Central Nervous System disturbances, their evolution, and their comorbidities."


Sleep medicine Parasomnia Neurodegeneration Neurological disorders Dreams

Editors and affiliations

  • Carlos H. Schenck
    • 1
  • Birgit Högl
    • 2
  • Aleksandar Videnovic
    • 3
  1. 1.Minnesota Regional Sleep Disorders Center, Departments of PsychiatryUniversity of Minnesota Medical School and Hennepin County Medical CenterMinneapolisUSA
  2. 2.Department of NeurologyMedical University of InnsbruckInnsbruckAustria
  3. 3.Department of NeurologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2019
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-90151-0
  • Online ISBN 978-3-319-90152-7
  • Buy this book on publisher's site
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