© 2018

Molecular Mechanisms of Notch Signaling

  • Tilman Borggrefe
  • Benedetto Daniele Giaimo


  • Provides the most recent overview of Notch signal transduction

  • Is an in-depth introduction into molecular mechanisms of signal transduction exemplified by the Notch signaling pathway

  • Covers topics such as Notch signaling in combination with senescence, blood vessel formation, leukemogenesis, neurogenesis and stem cell functions


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1066)

Table of contents

  1. Front Matter
    Pages i-xxvii
  2. Introduction

    1. Front Matter
      Pages 1-1
  3. Molecular Mechanisms of Receptor/Ligand Interactions

    1. Front Matter
      Pages 31-31
    2. Penny A. Handford, Boguslawa Korona, Richard Suckling, Christina Redfield, Susan M. Lea
      Pages 33-46
    3. Klaus N. Lovendahl, Stephen C. Blacklow, Wendy R. Gordon
      Pages 47-58
    4. Beth M. Harvey, Robert S. Haltiwanger
      Pages 59-78
    5. Udi Binshtok, David Sprinzak
      Pages 79-98
    6. Björn Schnute, Tobias Troost, Thomas Klein
      Pages 99-122
  4. Intracellular Signaling Mechanisms

    1. Front Matter
      Pages 123-123
    2. Diana M. Ho, K. G. Guruharsha, Spyros Artavanis-Tsakonas
      Pages 125-140
    3. Diana Bellavia, Saula Checquolo, Rocco Palermo, Isabella Screpanti
      Pages 205-222
    4. Anna Engler, Runrui Zhang, Verdon Taylor
      Pages 223-234
    5. Anna Bigas, Cristina Porcheri
      Pages 235-263
    6. Ryoichiro Kageyama, Hiromi Shimojo, Akihiro Isomura
      Pages 265-277
    7. Franz Oswald, Rhett A. Kovall
      Pages 279-295
  5. Disease Links and Therapeutics

    1. Front Matter
      Pages 297-297
    2. Matthew Hoare, Masashi Narita
      Pages 299-318

About this book


This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular domain from the membrane. The Notch intracellular domain migrates into the nucleus and activates gene expression.

Recently, new technologies allowed us to better understand this pivotal signaling cascade and revealed new regulatory mechanisms. The different chapters cover many aspects of the Notch signaling focusing on the mechanisms governing the receptor/ligand interaction as well as on the downstream intracellular signaling events. Aspects of both canonical and non-canonical signaling are discussed and the function of Notch signaling in physiological and pathological contexts are elucidated.

This book is not only intended for experts but it should also be a useful resource for young, sprouting scientists or interested scientists from other research areas, who may use this book as a stimulating starting point for further discoveries and developments.


Notch Receptor/ligand interaction Endosomal trafficking of the Notch Receptor Epigenetic Regulation of Notch Target Genes MicroRNAs in Notch Signalling Crosswalk between different signalling pathways

Editors and affiliations

  • Tilman Borggrefe
    • 1
  • Benedetto Daniele Giaimo
    • 2
  1. 1.Institute of BiochemistryUniversity of GiessenGiessenGermany
  2. 2.Institute of BiochemistryUniversity of GiessenGiessenGermany

Bibliographic information

  • Book Title Molecular Mechanisms of Notch Signaling
  • Editors Tilman Borggrefe
    Benedetto Daniele Giaimo
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-89511-6
  • Softcover ISBN 978-3-030-07789-1
  • eBook ISBN 978-3-319-89512-3
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages XXVII, 398
  • Number of Illustrations 3 b/w illustrations, 56 illustrations in colour
  • Topics Receptors
    Protein-Ligand Interactions
    Protein Structure
  • Buy this book on publisher's site