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Modeling Methods for Medical Systems Biology

Regulatory Dynamics Underlying the Emergence of Disease Processes

  • María Elena  Álvarez-Buylla Roces
  • Juan Carlos Martínez-García
  • José Dávila-Velderrain
  • Elisa Domínguez-Hüttinger
  • Mariana Esther Martínez-Sánchez

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1069)

Table of contents

  1. Front Matter
    Pages i-xxi
  2. María Elena Álvarez-Buylla Roces, Juan Carlos Martínez-García, José Dávila-Velderrain, Elisa Domínguez-Hüttinger, Mariana Esther Martínez-Sánchez
    Pages 1-33
  3. María Elena Álvarez-Buylla Roces, Juan Carlos Martínez-García, José Dávila-Velderrain, Elisa Domínguez-Hüttinger, Mariana Esther Martínez-Sánchez
    Pages 35-134
  4. María Elena Álvarez-Buylla Roces, Juan Carlos Martínez-García, José Dávila-Velderrain, Elisa Domínguez-Hüttinger, Mariana Esther Martínez-Sánchez
    Pages 135-209
  5. Back Matter
    Pages 211-258

About this book

Introduction

This book contributes to better understand how lifestyle modulations can effectively halt the emergence and progression of human diseases. The book will allow the reader to gain a better understanding of the mechanisms by which the environment interferes with the bio-molecular regulatory processes underlying the emergence and progression of complex diseases, such as cancer. Focusing on key and early cellular bio-molecular events giving rise to the emergence of degenerative chronic disease, it builds on previous experience on the development of multi-cellular organisms, to propose a mathematical and computer based framework that allows the reader to analyze the complex interplay between bio-molecular processes and the (micro)-environment from an integrative, mechanistic, quantitative and dynamical perspective.  Taking the wealth of empirical evidence that exists it will show how to build and analyze models of core regulatory networks involved in the emergence and progression of chronic degenerative diseases, using a bottom-up approach.


Keywords

Morphogenesis Systems dynamics chronic disease degenerative biomolecular immune response regulation Core regulatory networks

Authors and affiliations

  • María Elena  Álvarez-Buylla Roces
    • 1
  • Juan Carlos Martínez-García
    • 2
  • José Dávila-Velderrain
    • 3
  • Elisa Domínguez-Hüttinger
    • 4
  • Mariana Esther Martínez-Sánchez
    • 5
  1. 1.Ciudad Universitaria, UNAM, Instituto de EcologíaCiudad de MéxicoMexico
  2. 2.Departamento de Control AutomáticoCINVESTAVCiudad de MéxicoMexico
  3. 3.CSIL, Massachusetts Institute of TechnologyCambridgeUSA
  4. 4.Centro de Ciencias Matemáticas, UNAMMoreliaMexico
  5. 5.Ciudad Universitaria, UNAM, Instituto de EcologíaCiudad de MéxicoMexico

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-89354-9
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-89353-2
  • Online ISBN 978-3-319-89354-9
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site
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