© 2019

Unraveling the Exposome

A Practical View

  • Sonia Dagnino
  • Anthony Macherone

Table of contents

  1. Front Matter
    Pages i-xii
  2. The Utility of the Exposome Paradigm

    1. Front Matter
      Pages 1-1
    2. Martyn T. Smith, Cliona M. McHale, Rosemarie de la Rosa
      Pages 3-22
    3. Paul D. Juarez
      Pages 23-61
    4. Christopher Bradburne, John A. Lewis
      Pages 63-85
    5. Jessica E. Laine, Oliver Robinson
      Pages 87-123
  3. Measuring the Internal Exposome

    1. Front Matter
      Pages 125-125
    2. Michelle Plusquin, Nelly D. Saenen, Tim S. Nawrot
      Pages 127-146
    3. Toby Athersuch
      Pages 147-181
    4. D. A. Sarigiannis
      Pages 183-214
  4. Measuring Sources of Exposure

    1. Front Matter
      Pages 215-215
    2. Augustin Scalbert, Inge Huybrechts, Marc J. Gunter
      Pages 217-245
    3. I. R. Schultz, S. Cade, L. J. Kuo
      Pages 247-254
  5. Data Analysis for the Exposome

  6. Exposome Characterization Around the Globe

    1. Front Matter
      Pages 337-337
    2. Megan M. Niedzwiecki, Gary W. Miller
      Pages 339-348
    3. Christiana A. Demetriou, Davide Degli Esposti, Kristi Pullen Fedinick, Paolo Vineis
      Pages 349-392

About this book


This volume presents a comprehensive overview of the science and application of the Exposome through seventeen chapters from leaders in the field. At just over ten years since the term was coined by Christopher Wild in 2005, this is the first, field-defining volume to offer a holistic picture of the important and growing field of Exposomics. 

The term “Exposome” describes the sum of all exposures (not only chemical) that an individual can receive over a lifetime from both exogenous sources (environmental contaminants, food, lifestyle, drugs, air, etc.) and endogenous sources (metabolism, oxidative stress, lipid peroxidation, chemicals synthesized by the microbiome, etc.). The first section of this book contains chapters that discuss how the Exposome is defined and how the concept fits into the fields of public health and epidemiology. The second section provides an overview of techniques and methods to measure the human Exposome. The third section contains methods and applications for measuring the Exposome through external exposures. Section four provides an overview on statistical and computational techniques – including big data analysis - for characterizing the Exposome. Section five presents a global collection of case studies. 


Environmental exposures Exogenous and endogenous exposures Characterizing the exposome Environmental Epidemiology Food metabolomics Workplace and household contaminants Epigenetics

Editors and affiliations

  • Sonia Dagnino
    • 1
  • Anthony Macherone
    • 2
  1. 1.Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public HealthImperial College LondonLondonUK
  2. 2.The Johns Hopkins School of MedicineAgilent TechnologiesBaltimoreUSA

About the editors

Dr. Sonia Dagnino is currently a Marie Sklodowska-Curie Research Fellow at the Epidemiology and Biostatistics Department at Imperial College London, School of Public Health. Dr. Sonia Dagnino's research is focused on the development of new methodologies for the understanding of the exposome and its implications for human health. Dr. Dagnino is actively engaged in several research projects on the exposome worldwide and has an extensive expertise in this field.

Dr. Macherone serves as a Senior Scientist with Agilent Technologies and a Visiting Professor at the Johns Hopkins School of Medicine. He is also on the faculty of P2i (Preconception 2 infancy) with a focus of providing “women and couples tools to improve their odds of healthy, full-term pregnancies, thus reducing the incidence of serious, chronic disorders among their children”. Dr. Macherone is an expert in exposomics and is actively engaged in several publicly or privately funded exposomics investigations. 

Bibliographic information