Varicocele and Male Infertility

A Complete Guide

  • Sandro C Esteves
  • Chak-Lam Cho
  • Ahmad Majzoub
  • Ashok Agarwal

Table of contents

  1. Front Matter
    Pages i-xxvii
  2. Varicocele Origin and Pathophysiology

    1. Front Matter
      Pages 1-1
    2. Neel Parekh, Edmund Sabanegh Jr.
      Pages 17-26
    3. Viviane Paiva Santana, Cristiana Libardi Miranda-Furtado, Rosana Maria dos Reis
      Pages 37-53
    4. Ahmad Majzoub, Chak-Lam Cho, Ashok Agarwal, Sandro C. Esteves
      Pages 55-71
    5. Manesh Kumar Panner Selvam, Ashok Agarwal
      Pages 73-85
    6. Fatima Kazue Okada, Renata Cristina de Carvalho, Ricardo Pimenta Bertolla
      Pages 87-94
  3. Clinical Evaluation of Varicocele

    1. Front Matter
      Pages 95-95
    2. Daniel Lybbert, Nicholas N. Tadros
      Pages 107-114
    3. Mohamed Arafa, Haitham Elbardisi
      Pages 115-121
    4. Muhannad M. Alsyouf, Phillip K. Stokes, Edmund Y. Ko
      Pages 123-135
    5. Ahmad Majzoub, Chak-Lam Cho, Ashok Agarwal, Sandro C. Esteves
      Pages 137-157
    6. Benjamin J. McCormick, R. Matthew Coward
      Pages 171-182
  4. Varicocele Therapy

    1. Front Matter
      Pages 183-183
    2. Gian Maria Busetto, Francesco Del Giudice, Ettore De Berardinis
      Pages 185-199
    3. Sarah C. Krzastek, Connor Rotterman, Ryan P. Smith, Jason R. Kovac
      Pages 201-208
    4. Russell P. Hayden, Marc Goldstein
      Pages 209-223
    5. Roberto Mendez-Gallart, Maria Garcia-Palacios
      Pages 225-233
    6. Walid M. Mubarak, Jehan AlRayahi, Ashley James Robinson
      Pages 235-244
    7. Mohamed H. Etafy, Richard A. Mendelson, Sijo J. Parekattil
      Pages 245-253
    8. S. V. Krishna Reddy, Ahammad Basha Shaik
      Pages 255-269
    9. Siddharth Yadav, Rajeev Kumar
      Pages 285-294
    10. Joseph Scott Gabrielsen, Nannan Thirumavalavan, Alexander W. Pastuszak
      Pages 295-301
    11. Parviz Keikhosrow Kavoussi
      Pages 303-312
    12. Giorgio Ivan Russo, Ege Can Serefoglu
      Pages 325-332
    13. Alexander D. Doudt, Matthew S. Christman
      Pages 343-355
  5. Controversies Surrounding Varicocele

  6. Varicocele Debates: Pro and Con

    1. Front Matter
      Pages 451-451
    2. Nannan Thirumavalavan, Joseph Scott Gabrielsen, Alexander W. Pastuszak
      Pages 467-475
    3. Samuel J. Ohlander, Rodrigo L. Pagani, Craig S. Niederberger
      Pages 477-483

About this book


This unique textbook – the first of its kind – presents a thoughtful and comprehensive discussion of the significance of varicocele and its impact on male fertility. This hot topic is covered from a multitude of angles in seven thematic sections: origin and pathophysiology, clinical evaluation, medical and surgical therapy, controversies, pro and con debates, and clinical case scenarios. The scope of varicocele includes basic and transitional research, genetics, diagnostic testing with conventional and advanced molecular biology approaches, hormonal control, interventional therapy and assisted reproductive technology (ART). Repair of varicocele, which can be carried out by various methods, not only alleviates oxidative stress‐associated infertility but also prevents and protects against the progressive character of varicocele and its consequent upregulations of systemic oxidative stress. 

Even with the advances in the understanding of this intriguing disease and consensus on some areas such as diagnosis and pathophysiology, substantial controversy still exists, in particular concerning the benefits of treatment and to whom treatment should be offered. Additional chapters discuss, in depth, such controversies surrounding the role of varicocele in male infertility and present clinical case scenarios dealing with management of subclinical and clinical varicocele. A series of editorial comments is provided by the editors at the end of selected chapters, containing an objective and concise summary of the information from each chapter. In addition, chapters open up with key points for quick references and conclude with multiple choice questions and answers for immediate review and retention of the rich content.

Generously illustrated, Varicocele and Male Infertility: A Complete Guide represents an invaluable tool for medical students in reproductive medicine as well as researchers and clinicians working in the field of infertility (e.g., urologists, gynecologists, reproductive endocrinologists, and embryologists) and is comprised of chapters written by leading and internationally recognized clinicians and scientists with expertise in varicocele, skillfully edited by leaders in the field.


Assisted reproductive technology (ART) Azoospermia Bilateral repair Male infertility Microsurgery Orchialgia Oxidative stress Semen analysis Semen quality Seminal plasma Sperm function testing Subclinical varicocele Urological surgery Varicocele Varicocelectomy

Editors and affiliations

  • Sandro C Esteves
    • 1
  • Chak-Lam Cho
    • 2
  • Ahmad Majzoub
    • 3
  • Ashok Agarwal
    • 4
  1. 1.ANDROFERTAndrology & Human Reproduction ClinicCampinasBrazil
  2. 2.S.H. Ho Urology Centre, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong KongHong KongHong Kong
  3. 3.Department of UrologyHamad Medical Corporation, Weill Cornell Medicine QatarDohaQatar
  4. 4.Department of Urology, Cleveland ClinicClevelandUSA

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