© 2018

Gene Therapy in Reconstructive and Regenerative Surgery

  • Giorgio Giatsidis
  • Offers a practical overview of the latest research discoveries and clinical trials in the field of gene therapy

  • Written by prominent surgeons

  • Also includes a chapter on how to develop gene therapy clinical trials


Table of contents

  1. Front Matter
    Pages i-vii
  2. Kristo Nuutila, Mansher Singh, Elof Eriksson
    Pages 11-35
  3. Chenyu Huang, Longwei Liu, Zhifeng You, Yanan Du, Rei Ogawa
    Pages 37-48
  4. Adriana C. Panayi, Shane M. Lince, Indranil Sinha
    Pages 49-69
  5. Sheri Wang, Bing Wang
    Pages 71-82
  6. Raman Mehrzad, Xiao Tian Wang, You Lang Zhou, Ya Fang Wu, Paul Y. Liu
    Pages 83-89
  7. Christopher R. Davis, Peter A. Than, Geoffrey C. Gurtner
    Pages 91-101
  8. Raman Mehrzad, Paul Y. Liu
    Pages 103-110

About this book


This book offers an updated overview of the most recent research advances in the field, a comparison of established techniques and methods, a discussion on current experimental and translational challenges, and a commentary on potential opportunities and future directions.

Dedicated chapters address and review the preclinical and clinical state-of-the-art of gene therapies for the reconstructive and regenerative surgery of skin and wounds, pathological scars, cartilage, tendons, skeletal muscles, and bio-engineered flaps. A brief guide to developing gene therapy clinical trials in the context of reconstructive and regenerative surgery is also provided.
Biomedical and technological innovations are transforming our capacity to use gene therapies to safely and effectively repair, reconstruct, and regenerate tissues that are deficient or have been damaged by trauma and diseases. The targeted and controlled modulation of gene expression in tissues represents a game-changing, next-generation therapeutic tool for the modern reconstructive surgeon, expanding the horizon of regenerative surgery and tissue engineering. Through gene therapies, surgeons can direct (stem) cell differentiation and cell function, modulate the release of growth/transcriptional factors, affect the biological properties of regenerative scaffolds, control tissue inflammation, or induce immune-suppression in composite tissue allotransplants and xenotransplants.

Written by renowned reconstructive surgeons and leading experts in each of these fields - from top academic institutions around the globe, the book provides an initial practical guide for veteran and newcomer surgeons alike, as well as for researchers interested in exploring the latest gene-based therapeutic strategies for reconstructive and regenerative surgery.


Regenerative medicine Vectors Gene delivery Growth factors Wound healing Scars and Keloids Skeletal Muscle Angiogenesis Tendon Cartilage Flaps Clinical Trials CRISPR micro-RNA Tissue Engineering Genetic editing

Editors and affiliations

  • Giorgio Giatsidis
    • 1
  1. 1.Division of Plastic Surgery, Department of SurgeryBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA

About the editors

Dr. Giorgio Giatsidis received his medical degree from the San Raffaele University (Milan, Italy) in 2009. He completed his training in plastic, reconstructive and aesthetic surgery at the University of Padova (Padova, Italy) in 2015, where he also received his Ph.D. in Molecular Biology & Regenerative Medicine in 2018.
Since 2013, he has been conducting research on tissue engineering and regeneration in the Division of Plastic Surgery of Brigham and Women’s Hospital and at Harvard Medical School (Boston, USA), joining the faculty of both Institutions later in 2015. He also holds collaborative appointments at the Boston Children`s Hospital (Boston, USA) and the San Raffaele Hospital (Milan, Italy).
Dr. Giatsidis has several roles in scientific societies and an ad hoc reviewer for multiple scientific journals in the field. His research has been funded by federal sources (the U.S. Department of Defense) and private foundations. Currently, he is a national delegate for Italy in the Research Council of the European Association of Plastic Surgeons (EURAS).

Bibliographic information

  • Book Title Gene Therapy in Reconstructive and Regenerative Surgery
  • Editors Giorgio Giatsidis
  • DOI
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-319-78956-9
  • Softcover ISBN 978-3-030-07689-4
  • eBook ISBN 978-3-319-78957-6
  • Edition Number 1
  • Number of Pages VII, 113
  • Number of Illustrations 1 b/w illustrations, 7 illustrations in colour
  • Topics Plastic Surgery
    Regenerative Medicine/Tissue Engineering
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Surgery & Anesthesiology