Antimicrobial Resistance in the 21st Century

  • I. W. Fong
  • David Shlaes
  • Karl Drlica

Part of the Emerging Infectious Diseases of the 21st Century book series (EIDC)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Examples of Resistance

    1. Front Matter
      Pages 11-11
    2. Catia Cillóniz, Carolina Garcia-Vidal, Adrian Ceccato, Antoni Torres
      Pages 13-38
    3. Lacey P. Gleason, David C. Ham, Valerie Albrecht, Isaac See
      Pages 39-69
    4. Charles R. Dean, Gianfranco De Pascale, Bret Benton
      Pages 71-162
    5. Neil W. Schluger
      Pages 163-189
    6. William L. Drew, Jocelyne Piret, Guy Boivin
      Pages 233-267
    7. Karl Drlica, Bo Shopsin, Xilin Zhao
      Pages 269-296
  3. Biology of Resistance

    1. Front Matter
      Pages 297-297
    2. Patricia A. Bradford
      Pages 299-339
    3. George A. Jacoby
      Pages 341-381
    4. Marilyn C. Roberts
      Pages 383-407
    5. Bo Shopsin, Richard Copin
      Pages 431-459
    6. Andrew T. Ulijasz, Sarah C. Feid, David G. Glanville
      Pages 461-505
    7. Elizabeth G. Gibson, Rachel E. Ashley, Robert J. Kerns, Neil Osheroff
      Pages 507-529
  4. Finding New Antimicrobials

    1. Front Matter
      Pages 531-531
    2. Fern R. McSorley, Jarrod W. Johnson, Gerard D. Wright
      Pages 533-562
    3. Anthony Maxwell, Natassja G. Bush, Thomas Germe, Shannon J. McKie
      Pages 593-618
    4. Yuzhi Hong, Karl Drlica, Xilin Zhao
      Pages 619-642
    5. Alexander A. Firsov, Yury A. Portnoy, Stephen H. Zinner
      Pages 643-666
  5. Bringing Compounds to Market

    1. Front Matter
      Pages 667-667
    2. Justin C. Bader, Elizabeth A. Lakota, Brian VanScoy, Sujata M. Bhavnani, Paul G. Ambrose
      Pages 669-705
  6. Back Matter
    Pages 755-775

About this book


 Antimicrobial resistance is now a general problem. Many of us have elderly relatives who died from a drug-resistant infection, and some of us have suffered from a resistant urinary infection that likely came from intestinal bacteria following antibiotic consumption. Antimicrobial Resistance in the 21st Century provides a broad introduction to the subject in which the situation with problematic pathogens is detailed, the biology of resistance is described, and gaining approval for new antibiotics is discussed. Some topics are immediately practical, such as watching for resistant pathogen sub-populations in cultures taken from patients; other topics point to future research efforts that may lead to new antimicrobials and ways to stimulate the action of existing ones. Overall, Antimicrobial Resistance in the 21st Century provides an update for physicians, serves as a starting point for graduate students interested in solving the resistance problem, and may serve as a text for a course on resistance. Lay readers familiar with microbiology will gain an appreciation for a medical issue that promises to be one of the most important of our time. 

Ignatius Fong, Department of Medicine, University of Toronto 

Series Editor – Emerging Infectious Diseases of the 21st Century 

David Shlaes, Founder, Anti-Infectives Consulting 

Editor – Antimicrobial Agents and Chemotherapy

Karl Drlica, The Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey


Epidemiology HIV antimicrobial antimicrobial resistance bacteria infection infections prevention sexually transmitted infection virus

Editors and affiliations

  • I. W. Fong
    • 1
  • David Shlaes
    • 2
  • Karl Drlica
    • 3
  1. 1.Department of MedicineUniversity of TorontoTorontoCanada
  2. 2.Anti-infectives Consulting, LLCStoningtonUSA
  3. 3.Public Health Research InstituteNew Jersey Medical School, Rutgers Biomedical and Health SciencesNewarkUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-78537-0
  • Online ISBN 978-3-319-78538-7
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals