© 2018

Sex-Specific Analysis of Cardiovascular Function

  • Peter L. M. Kerkhof
  • Virginia M. Miller


  • Gathers together contributions from internationally renowned authors in the field of cardiovascular systems

  • Presents a multidisciplinary approach to the understanding of sex-related properties concerning the heart and the vascular system

  • Utilizes genome analysis, description of (sub)cellular function, (electro)physiology, high resolution imaging methods, signal analysis, and advanced simulation studies


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1065)

Table of contents

  1. Front Matter
    Pages i-xxiv
  2. Marieke M. ter Wee, Birgit I. Lissenberg-Witte
    Pages 71-92
  3. Robbert Zusterzeel
    Pages 107-121
  4. Peter L. M. Kerkhof, Tatiana Kuznetsova, J. Yasha Kresh, Neal Handly
    Pages 123-138
  5. Jane F. Reckelhoff
    Pages 139-151
  6. Alberto P. Avolio, Tatiana Kuznetsova, Guy R. Heyndrickx, Peter L. M. Kerkhof, John K.-J. Li
    Pages 153-168
  7. Mireia Calvo, Virginie Le Rolle, Daniel Romero, Nathalie Béhar, Pedro Gomis, Philippe Mabo et al.
    Pages 181-190
  8. Massimo Pagani, Roberto Sala, Mara Malacarne, Daniela Lucini
    Pages 191-205
  9. Carlo Dal Lin, Francesco Tona, Elena Osto
    Pages 225-239
  10. Rosa Vona, Barbara Ascione, Walter Malorni, Elisabetta Straface
    Pages 241-256
  11. Viviany R. Taqueti
    Pages 257-278
  12. Aurangzeb Memon, Louise D. McCullough
    Pages 279-290

About this book


This book gathers together contributions from internationally renowned authors in the field of cardiovascular systems and provides crucial insight into the importance of sex- and gender-concepts during the analysis of patient data. This innovative title is the first to offer the elements necessary to consider sex-related properties in both clinical and basic studies regarding the heart and circulation on multiscale levels (i.e. molecular, cellular, electrophysiologically, neuroendocrine, immunoregulatory, organ, allometric, and modeling). Observed differences at (ultra)cellular and organ level are quantified, with focus on clinical relevance and implications for diagnosis and patient management. Since the cardiovascular system is of vital importance for all tissues, Sex-Specific Analysis of Cardiovascular Function is an essential source of information for clinicians, biologists, and biomedical investigators. The wide spectrum of differences described in this book will also act as an eye-opener and serve as a handbook for students, teachers, scientists and practitioners.


sex-specific personalized medicine gender-specific vascular systems sex-specific medicine gender-specific electrophysiology cellular function sex-specific e-cardiology sex-specific vascular systems gender-specific e-cardiology genome analysis signal analysis gender-specific personalized medicine sex-specific electrophysiology gender-specific medicine

Editors and affiliations

  • Peter L. M. Kerkhof
    • 1
  • Virginia M. Miller
    • 2
  1. 1.Department of Radiology and Nuclear MedicineAmsterdam Cardiovascular Sciences, VU University Medical CenterAmsterdamThe Netherlands
  2. 2.Mayo ClinicRochesterUSA

About the editors

Peter L. M. Kerkhof, Studying at Leiden University, Peter LM Kerkhof completed his PhD thesis on clinical physiology (Dept. Pediatrics). His novel approach to analyzing cardiac pump function won him a Young Investigator’s Award at the World Congress of Cardiology, Moscow, 1982. As an NIH Fogarty Fellow he joined Harvard Medical School, and next Bioengineering at the University of Pennsylvania. He was organizer and chairman of the VIth International Meeting on Clinical Laboratory Organization and Management, The Netherlands, 1987. At AMA in Chicago he was Distin­guished Lecturer in Medical Scie­nce in 1990, and at Rutgers University in 1996 visiting professor in Bioengineering. For two decades he served as associate editor of IEEE Trans BME, and acted as guest editor. He edited three books, and published on cardiology and medical informatics. While interested in computer assisted diagnosis, he is also associated with Radiology and Nuclear Medicine, VUMC, Amsterdam, where his focus is on pediatric cardiology, heart transplantation, and sex-related issues in heart failure.

Virginia M. Miller, PhD, is Professor of Surgery and Physiology and Director of the Women’s Health Research Center at Mayo Clinic, Rochester, MN.  Trained as a comparative physiologist at the University of Missouri, Columbia, MO, her work has spanned basic studies of temperature regulation in hibernating animals, brain pathways involved with spatial memory, hormonal influences on the vascular endothelium and platelets in experimental animals to sex-specific risk (i.e. hypertensive pregnancy disorder, oophorectomy and natural menopause) for vascular dysfunction and cognitive decline in women.  Her interdisciplinary approach to promoting research in sex differences has won her several awards including the Bernadine Healy Award for Visionary Leadership in Women’s Health and the Women’s Day Magazine Red Dress Award for promoting heart health in women.  Topics in this book reflect her passion for mentoring the next generation of basic and clinical scientists to fill the knowledge gaps in understanding how biological sex influences health and disease.

Bibliographic information

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