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The Heterogeneity of Cancer Metabolism

  • Anne Le

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1063)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Basic Metabolism of Cancer Cells

    1. Front Matter
      Pages 1-1
    2. Sminu Bose, Anne Le
      Pages 3-12
    3. Ting Li, Anne Le
      Pages 13-32
    4. Joshua K. Park, Nathan J. Coffey, Aaron Limoges, Anne Le
      Pages 33-55
  3. Heterogeneity of Cancer Metabolism

    1. Front Matter
      Pages 57-57
    2. Addison Quinones, Anne Le
      Pages 59-72
    3. Felipe Camelo, Anne Le
      Pages 73-81
    4. Jessica Tan, Anne Le
      Pages 83-93
    5. Brian James Kirsch, Shu-Jyuan Chang, Anne Le
      Pages 95-106
    6. Marjorie Justine Antonio, Anne Le
      Pages 119-129
    7. Karim Nabi, Anne Le
      Pages 131-145
  4. Relationship between Cancer Cells and Cancer-Associated Fibroblasts

  5. Back Matter
    Pages 179-183

About this book

Introduction

Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor.

In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Keywords

cancer cell metabolism glucose metabolism glutamine metabolism amino acid metabolism lipid metabolism epigenetics and oncometabolites

Editors and affiliations

  • Anne Le
    • 1
  1. 1.Johns Hopkins MedicineBaltimoreUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-77736-8
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-77735-1
  • Online ISBN 978-3-319-77736-8
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site
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