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Complement Activation in Malaria Immunity and Pathogenesis

  • José A. Stoute

Table of contents

  1. Front Matter
    Pages i-xii
  2. Sergei Biryukov, José A. Stoute
    Pages 1-29
  3. Ronald P. Taylor, José A. Stoute, Margaret A. Lindorfer
    Pages 31-49
  4. José A. Stoute
    Pages 51-64
  5. Theresa N. Schein, Scott R. Barnum
    Pages 65-90
  6. Andrea Weckman, Vanessa Tran, Kevin C. Kain
    Pages 91-105
  7. Alexander T. Kennedy, Christoph Q. Schmidt, Wai-Hong Tham
    Pages 107-124
  8. José A. Stoute
    Pages 125-137
  9. Elena A. Levashina, Richard H. G. Baxter
    Pages 139-146
  10. Back Matter
    Pages 147-149

About this book

Introduction

Plasmodium falciparum malaria is responsible for the deaths of nearly 500,000 people each year. Much attention has been paid to antibody and cellular mechanisms of immunity against this pathogen. By contrast, the role that the complement system plays in immunity and pathogenesis in this infection is not very well recognized or understood. Based on the work of a number of research groups, we know that complement plays an important role in these processes. In this book, some of the leading scientists in the field discuss the mechanisms of complement activation during malaria infection as well as the role of complement in the pathogenesis of key syndromes such as severe malarial anemia, cerebral malaria, and placental malaria. In addition, they review recently-identified complement evasion strategies of P. falciparum merozoites, and how these mechanisms may translate into paradoxical enhancement of infection rather than protection. Finally, they also discuss the role of the mosquito complement system on immunity against the parasite. 

Keywords

malaria complement immunity immune evasion complement activation

Editors and affiliations

  • José A. Stoute
    • 1
  1. 1.Department of Medicine, and Microbiology and ImmunologyPenn State University College of MedicineHersheyUSA

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