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© 2018

Theoretical and Applied Aspects of Systems Biology

  • Fabricio Alves Barbosa da Silva
  • Nicolas Carels
  • Floriano Paes Silva Junior
  • Presents theoretical foundations of Systems Biology

  • Lists applications in studies on human hosts, pathogens and associated diseases

  • Topics discussed include computational modeling of multi-resistant bacteria, systems biology of cancer, systems immunology and networks in systems biology

Book

Part of the Computational Biology book series (COBO, volume 27)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Fundamentals

    1. Front Matter
      Pages 1-1
    2. Rafael V. Carvalho, Fons J. Verbeek, Clarimar J. Coelho
      Pages 3-26
    3. Marcelo Trindade dos Santos, Ana Paula Barbosa do Nascimento, Fernando Medeiros Filho, Fabricio Alves Barbosa da Silva
      Pages 27-39
    4. Domenico Sgariglia, Alessandra Jordano Conforte, Luis Alfredo Vidal de Carvalho, Nicolas Carels, Fabricio Alves Barbosa da Silva
      Pages 41-55
    5. Marcio Argollo de Menezes
      Pages 57-69
    6. Stephen Woloszynek, Zhengqiao Zhao, Gregory Ditzler, Jacob R. Price, Erin R. Reichenberger, Yemin Lan et al.
      Pages 71-112
    7. Alexandre Galvão Patriota, Maciel Calebe Vidal, Davi Augusto Caetano de Jesus, André Fujita
      Pages 113-125
  3. Applied Systems Biology

    1. Front Matter
      Pages 127-127
    2. Edward Rietman, Jack A. Tuszynski
      Pages 139-157
    3. Melissa Lever, Thiago C. Hirata, Pedro S. T. Russo, Helder I. Nakaya
      Pages 159-173
    4. Alessandra Jordano Conforte, Milena Magalhães, Tatiana Martins Tilli, Fabricio Alves Barbosa da Silva, Nicolas Carels
      Pages 175-194
    5. Fabricio Alves Barbosa da Silva, Fernando Medeiros Filho, Thiago Castanheira Merigueti, Thiago Giannini, Rafaela Brum, Laura Machado de Faria et al.
      Pages 195-220
    6. Larissa Catharina, Marcio Argollo de Menezes, Nicolas Carels
      Pages 221-242
    7. Celia Martins Cortez, Maria Clicia Stelling de Castro, Vanessa de Freitas Rodrigues, Camila Andrade Kalil, Dilson Silva
      Pages 243-259

About this book

Introduction

Systems Biology is a rapidly expanding field and comprises the study of biological systems through mathematical modeling and the analysis of large volumes of biological data. This book presents the theoretical foundations of Systems Biology, as well as its application in studies on human hosts, pathogens and associated diseases.  This book presents several chapters written by renowned experts in the field. Some topics discussed in depth in this book include: computational modeling of multidrug-resistant bacteria, systems biology of cancer, systems immunology, cellular reprogramming, bio-modeling using Petri nets, computational modeling of neuronal circuits, reconstruction and analysis of gene regulatory networks.

Keywords

Systems Biology Precision Medicine Modeling and simulation of biological systems Systems Biology of cancer Networks in Systems Biology

Editors and affiliations

  • Fabricio Alves Barbosa da Silva
    • 1
  • Nicolas Carels
    • 2
  • Floriano Paes Silva Junior
    • 3
  1. 1.Graduate Program in Computational BiologyOswaldo Cruz FoundationRio de JaneiroBrazil
  2. 2.Graduate Program in Computational BiologyOswaldo Cruz FoundationRio de JaneiroBrazil
  3. 3.Graduate Program in Computational BiologyOswaldo Cruz FoundationRio de JaneiroBrazil

About the editors

Prof. Dr. Fabrício Alves Barbosa da Silva is the PI of the research group on computational modeling of multidrug-resistant bacteria at FIOCRUZ. The research group on computational modeling of multidrug-resistant bacteria proposes the creation of innovative models, techniques and computational methods to identify new potential therapeutic targets in multidrug-resistant bacteria using a systems biology approach. This multidisciplinary group is composed of researchers from six different institutions in Brazil.  Dr. Silva has expertise on computational biology, with focus on systems biology, mathematical modeling and the analysis and processing of large biological datasets. 

Prof. Dr. Nicolas Carels is the coordinator of the Laboratory of Biological System Modeling (LMSB) from the Center for Technological Development in Health (CDTS) of Oswaldo Cruz Foundation. Since the 1990s, he accumulated expertise in the genetics, biotechnology and bioinformatics of plant systems. More recently due to the availability of high throughput datasets in the context of the post-genomics era, he dedicated his activities to the bioinformatics of diseases’ molecular networks in the context of translational medicine. He is also investigating the metagenomics of microbial communities in interaction with human protozoan parasites in invertebrate hosts.

Prof. Dr. Floriano Paes Silva Junior is the head of the Laboratory of Computational and Experimental Biochemistry of Drugs (LaBECFar) at Oswaldo Cruz Institute, FIOCRUZ. Dr. Silva-Jr has expertise on Medicinal Chemistry and Chemical Biology working on the interface between computational and experimental approaches for drug discovery. His contributions include discovery and biochemical characterization of new drug targets and bioactive compounds with relevance to both infectious and non-communicable diseases. 

Bibliographic information

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