© 2018

Metabolic Interaction in Infection

  • Ricardo Silvestre
  • Egídio Torrado

Part of the Experientia Supplementum book series (EXS, volume 109)

Table of contents

  1. Front Matter
    Pages i-viii
  2. A Guide of Metabolism During Host–Pathogen Interactions

    1. Front Matter
      Pages 1-1
    2. Inês Mesquita, Fernando Rodrigues
      Pages 3-27
    3. Stella Maria Barrouin-Melo, Yadira Alejandra Morejón Terán, Johanna Anturaniemi, Anna Katrina Hielm-Björkman
      Pages 29-114
    4. Prashant Chauhan, Arup Sarkar, Bhaskar Saha
      Pages 115-196
    5. Inês Mesquita, Baptiste Vergnes, Ricardo Silvestre
      Pages 197-220
    6. Cynthia Soultawi, Yasmina Fortier, Calaiselvy Soundaramourty, Jérôme Estaquier, Mireille Laforge
      Pages 221-233
    7. Müberra Fatma Cesur, Ecehan Abdik, Ünzile Güven-Gülhan, Saliha Durmuş, Tunahan Çakır
      Pages 235-282
    8. Miguel Fernández-García, David Rojo, Fernanda Rey-Stolle, Antonia García, Coral Barbas
      Pages 283-315
  3. Microbial Metabolic Adaptation and Pathogen Rewiring of Host Cell Metabolism During Infection

    1. Front Matter
      Pages 317-317
    2. Catarina M. Ferreira, Ana Margarida Barbosa, Inês M. Pereira, Egídio Torrado
      Pages 319-350
    3. Elodie Gazanion, Baptiste Vergnes
      Pages 351-375
    4. Inês Mesquita, Jérôme Estaquier
      Pages 377-401
    5. Cláudia S. Rodrigues, Cláudia F. Campos, Cristina Cunha, Agostinho Carvalho
      Pages 403-420
    6. Diana Moreira, Jérôme Estaquier, Anabela Cordeiro-da-Silva, Ricardo Silvestre
      Pages 421-458
    7. José E. Belizário, Joel Faintuch
      Pages 459-476

About this book


This book focuses on host–pathogen interactions at the metabolic level. It explores the metabolic requirements of the infectious agents, the microbial metabolic pathways that are dedicated to circumvent host immune mechanisms as well as the molecular mechanisms by which pathogens hijack host cell metabolism for their own benefit. Finally, it provides insights on the possible clinical and immunotherapeutic applications, as well as on the available experimental and analytical methods. The contributions break new ground in understanding the metabolic crosstalk between host and pathogen.


Host-pathogen interactions Metabolism Microbial auxotrophy Infection Bioenergetics

Editors and affiliations

  • Ricardo Silvestre
    • 1
  • Egídio Torrado
    • 2
  1. 1.Life and Health Sciences Research InstituteUniversity of MinhoBragaPortugal
  2. 2.Life and Health Sciences Research InstituteUniversity of MinhoBragaPortugal

About the editors

Ricardo Silvestre is Principal Investigator at the Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Portugal. His research interest is to integrate the study of basic molecular and cellular mechanisms to develop a greater understanding of the immune-metabolic interface in innate immune cells. He addresses how the modifications of host cell metabolism and bioenergetics arising during inflammatory or infectious processes impact the immune functions of monocytes/macrophage and dendritic cells and the further consequences to tissue homeostasis with the objective of developing new approaches to prevention and treatment. 

Egídio Torrado is Assistant Researcher at the Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Portugal. His research is focused on the mechanisms that regulate the protective immune response to Mycobacterium tuberculosis
both during the innate and chronic phases of the infection. The emphasis of his work is on cytokines and the maintenance of the T cell response and the development of pathological consequences to the host.

Bibliographic information

  • Book Title Metabolic Interaction in Infection
  • Editors Ricardo Silvestre
    Egídio Torrado
  • Series Title Experientia Supplementum
  • Series Abbreviated Title Experientia Supplementum(Birkhäuser)
  • DOI
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-74931-0
  • Softcover ISBN 978-3-030-09108-8
  • eBook ISBN 978-3-319-74932-7
  • Series ISSN 1664-431X
  • Series E-ISSN 2504-3692
  • Edition Number 1
  • Number of Pages VIII, 476
  • Number of Illustrations 2 b/w illustrations, 43 illustrations in colour
  • Topics Molecular Medicine
    Biochemistry, general
    Medical Microbiology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals