© 2018

Biomedical Applications of Metals

  • Mahendra Rai
  • Avinash P. Ingle
  • Serenella Medici
  • Uniquely positioned to provide insights that are not affected by new trends and regulatory changes

  • Focuses on metals and their role in the diagnosis and treatment of disease

  • Covers toxicological issues and safety concerns

  • First to include research on Aryurvedic metal uses


Table of contents

  1. Front Matter
    Pages i-xviii
  2. Applications of Metals in Medicine

    1. Front Matter
      Pages 1-1
    2. Serenella Medici, Massimiliano Francesco Peana, Maria Antonietta Zoroddu
      Pages 3-48
    3. Massimiliano Francesco Peana, Serenella Medici, Maria Antonietta Zoroddu
      Pages 49-72
    4. Alexander L. Neuwirth, Blair S. Ashley, William M. Hardaker, Neil P. Sheth
      Pages 73-93
    5. Avinash P. Ingle, Priti Paralikar, Sudhir Shende, Indarchand Gupta, Jayanta Kumar Biswas, Luiza Helena da Silva Martins et al.
      Pages 95-112
    6. Luiza Helena da Silva Martins, Mahendra Rai, João Moreira Neto, Paulo Weslem Portal Gomes, Júlia Helena da Silva Martins
      Pages 113-127
    7. Natalie Gugala, Raymond J. Turner
      Pages 129-150
    8. Olga Sinitsyna, Priti Paralikar, Raksha Pandit, Mahendra Rai
      Pages 151-165
    9. Paulo Ricardo Franco Marcelino, Mariete Barbosa Moreira, Talita Martins Lacerda, Silvio Silvério da Silva
      Pages 167-193
    10. Reetika Singh, Bechan Sharma
      Pages 195-211
    11. Carmen Mejía, Said Ortega-Rosales, Lena Ruiz-Azuara
      Pages 213-234
  3. Toxicity of Metals

    1. Front Matter
      Pages 235-235
    2. Shruti Pandey, Anand Chaudhary
      Pages 237-255
    3. Jayanta Kumar Biswas, Mahendra Rai, Monojit Mondal, Avinash P. Ingle
      Pages 257-276
    4. Sanjay Mishra, Amit Kumar Mani Tiwari, Abbas Ali Mahdi
      Pages 277-295
    5. Abhishek Kumar, Nitika Singh, Rukmani Pandey, Vivek Kumar Gupta, Bechan Sharma
      Pages 297-319
  4. Back Matter
    Pages 321-325

About this book


Focused more specifically on the recent advances in applications of various metals and their complexes used in biomedicine, particularly in the diagnosis and treatment of chronic diseases. The editors give equal importance to other key aspects such as toxicological issues and safety concerns. The application of metals in the biomedical field is highly interdisciplinary and has a broad appeal across all biomedical specialties. Biomedical Applications of Metals is particularly focused on covering the role of metals in medicine and the development of novel therapeutic products and solutions in the form of alternative medicines, and some topics on Indian traditional medicine i.e., “Ayurveda”. In Section I, the book discusses the role of metals in medicines and include chapters on nanoparticles, noble metals, medical devices, copper. selenium, silver, and microbial pathogens; while Section II includes topics on metals toxicity including heavy metals, carcinogens, cancer therapy, Bhasma’s and chelating agents used in Ayurveda, and biochemical and molecular targets including actions of metals. These new and emerging concepts of applications of metals in medicine, their crucial role in management of microbial resistance, and their use in the treatment of various chronic diseases is essential information for toxicologists, and clinical and biomedical researchers.


heavy metals noble metals metal toxicity heavy metal carcinogens medical imaging and metals MRI contrasting agents Bhasma toxicity Cancer therapy microbial drug resistance metal medical device toxicity

Editors and affiliations

  • Mahendra Rai
    • 1
  • Avinash P. Ingle
    • 2
  • Serenella Medici
    • 3
  1. 1.Nanobiotechnology Laboratory, Department of BiotechnologySant Gadge Baba Amravati UniversityAmravatiIndia
  2. 2.Nanobiotechnology Laboratory, Department of BiotechnologySant Gadge Baba Amravati UniversityAmravatiIndia
  3. 3.Departmento Di Chimica FarmaciaUniversity of SassariSassariItaly

About the editors

Mahendra Rai is a Senior Professor at the Department of Biotechnology, Sant Gadge Baba Amravati University at Amravati, Maharashtra, India. He was a Visiting Scientist at the Department of Bioenergetics, University of Geneva, Switzerland in 2004 and at the Department of Plant Protection of Debrecen University, Debrecen, Hungary in 2005 and 2008. He visited Department of Chemical Biology, University of Campinas, Brazil under Indo-Brazil Research Programme (DST-CNPq collaboration) in 2009, 2011 and 2012. In 2012, he was visiting Professor in Nicolaus Copernicus University, Torun, Poland. In 2013, he was visiting scientist in State University of Campinas, Brazil. He was also visiting professor in 2015 in Ostrava, Czech Republic and in 2016 in National University of Rosario, Argentina. His area of expertise includes microbial biotechnology and nanobiotechnology. His present research interest include application of nanobiotechnology in medicine with particular reference to development of nanoantimicrobials. He has published more than 350 research papers in national and international journals. In addition, he has edited/authored more than 40 books and 6 patents. Recently, he has been awarded Basic Science Research Faculty Fellowship by University Grants Commission, New Delhi, Government of India.

Dr. Avinash P. Ingle has completed his doctoral degree from Department of Biotechnology, Sant Gadge Baba Amravati University, Amravati, Maharashtra (India) in 2012. Further, he worked as Research Scientist in the same department from 2013-2016. He has more than 55 research publications, 26 book chapters and 1 book to his credit. He has been awarded travel grants from different funding/sponsoring agencies to present his research work in international conferences held at Malaysia, China, Spain and France. His area of research mainly includes microbial biotechnology, nanobiotechnology and biofuel technology. Currently Dr. Ingle is working as Post-Doctoral Fellow at Department of Biotechnology, Engineering School of Lorena - University of São Paulo, Brazil and he is actively engaged in development nanotechnology based methods for the efficient production of biofuels.

Serenella Medici currently working as Assistant professor of General and Inorganic Chemistry at the University of Sassari, Italy, after receiving her PhD in Chemistry in Sassari she worked as a Post-Doctoral Fellow at the Debye Institute, University of Utrecht (the Netherlands), and was a visiting researcher at the Rovira i Virgili University (Tarragona, Spain) and Cerm (Centre for Magnetic Resonances, University of Florence, Italy). Her research interests include the study of organometallic complexes, metal ion-protein interactions, toxicity mechanisms and carcinogenesis of heavy metals, NMR applications and archaeometry.

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