Exosomes, Stem Cells and MicroRNA

Aging, Cancer and Age Related Disorders

  • Karl L. Mettinger
  • Pranela Rameshwar
  • Vinod Kumar

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1056)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Part I

    1. Front Matter
      Pages 1-1
    2. Catharine Dietrich, Manish Singh, Nishant Kumar, Shree Ram Singh
      Pages 11-26
  3. Part II

    1. Front Matter
      Pages 27-28
    2. Robert W. Brooks, Paul D. Robbins
      Pages 29-45
    3. Shyam Sundar Nandi, Paras Kumar Mishra
      Pages 47-59
    4. Kiminobu Sugaya, Manjusha Vaidya
      Pages 61-84
  4. Part III

    1. Front Matter
      Pages 85-86
    2. Simone Anfossi, Xiao Fu, Rahul Nagvekar, George A. Calin
      Pages 87-108
    3. Yin Huang, Keli Liu, Qing Li, Yikun Yao, Ying Wang
      Pages 109-122
    4. Jacob A. Tickner, Derek J. Richard, Kenneth J. O’Byrne
      Pages 123-135
    5. Oleta A. Sandiford, Caitlyn A. Moore, Jun Du, Mathieu Boulad, Marina Gergues, Hussam Eltouky et al.
      Pages 137-152

About this book


This volume provides insight into the pivotal roles of stem cells, exosomes and other microvesicles in biofunction and molecular mechanisms and their therapeutic potential in translational nanomedicine. It further highlights evidence from recent studies as to how stem cell derived exosomes and microRNAs may restore and maintain tissue homeostasis, enable cells to recover critical cellular functions and begin repair regeneration. These early studies in animal models of aging also show evidence of improved immune, cardiovascular and cognitive functions as well as improved health span and life span. The use of exosomes from body fluids to define specific biomarkers for various tumors may also clear the path to patient-targeted treatments by developing exosome-derived microRNA based cancer therapeutics. It is essential reading for graduate students, research fellow and biomedical researchers in academia or the pharmaceutical or biotech industries.


Extracellular vesicles Mesenchymal stem cells miRNA Tissue engineering Tumor biomarkers

Editors and affiliations

  • Karl L. Mettinger
    • 1
  • Pranela Rameshwar
    • 2
  • Vinod Kumar
    • 3
  1. 1.Cellastra Inc.San FranciscoUSA
  2. 2.Rutgers New Jersey Medical SchoolNewarkUSA
  3. 3.Novartis Pharmaceutical Corp.East HanoverUSA

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