Handbook of Sepsis

  • W. Joost Wiersinga
  • Christopher W. Seymour

Table of contents

  1. Front Matter
    Pages i-viii
  2. Sepsis: An Overview

    1. Front Matter
      Pages 1-1
    2. Luuk Giesen, Mervyn Singer
      Pages 3-14
    3. Hallie C. Prescott
      Pages 15-28
  3. The Pathogenesis of Sepsis

    1. Front Matter
      Pages 29-29
    2. Tjitske S. R. van Engelen, W. Joost Wiersinga, Tom van der Poll
      Pages 31-43
    3. Marcel Levi
      Pages 45-59
    4. Nicholas Heming, Sivanthiny Sivanandamoorthy, Paris Meng, Djillali Annane
      Pages 61-79
    5. Jean-Louis Vincent, Christophe Lelubre
      Pages 81-94
  4. Sepsis Management

    1. Front Matter
      Pages 95-95
    2. Radu Postelnicu, Andrew Rhodes, Laura Evans
      Pages 97-111
    3. James R. Anstey, Adam M. Deane, Rinaldo Bellomo
      Pages 113-126
    4. Julian Arias Ortiz, Daniel De Backer
      Pages 127-138
    5. Ithan D. Peltan, Samuel M. Brown
      Pages 139-158
    6. Russell J. McCulloh, Steven M. Opal
      Pages 159-184
    7. Thierry Calandra, Benoît Guery
      Pages 185-199
    8. G. P. Leijte, M. Kox, P. Pickkers
      Pages 201-214
  5. Sepsis in the Coming Decade

    1. Front Matter
      Pages 215-215
    2. Christopher W. Seymour, Derek C. Angus
      Pages 217-230
    3. Luciano Cesar Pontes Azevedo, Flavia Ribeiro Machado
      Pages 231-251
    4. Jianfeng Xie, Craig M. Coopersmith
      Pages 253-267

About this book


This practically oriented book provides an up-to-date overview of all significant aspects of the pathogenesis of sepsis and its management, including within the intensive care unit. Readers will find information on the involvement of the coagulation and endocrine systems during sepsis and on the use of biomarkers to diagnose sepsis and allow early intervention. International clinical practice guidelines for the management of sepsis are presented, and individual chapters focus on aspects such as fluid resuscitation, vasopressor therapy, response to multiorgan failure, antimicrobial therapy, and adjunctive immunotherapy. The closing section looks forward to the coming decade, discussing novel trial designs, sepsis in low- and middle-income countries, and emerging management approaches. The book is international in scope, with contributions from leading experts worldwide. It will be of value to residents and professionals/practitioners in the fields of infectious diseases and internal medicine, as well as to GPs and medical students.


Sepsis Intensive Care Management Pathogenesis Antibiotics Surviving Sepsis Campaign

Editors and affiliations

  • W. Joost Wiersinga
    • 1
  • Christopher W. Seymour
    • 2
  1. 1.University of AmsterdamAmsterdamThe Netherlands
  2. 2.University of PittsburghPittsburghUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-73505-4
  • Online ISBN 978-3-319-73506-1
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Public Health
Internal Medicine & Dermatology