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Accelerated Path to Cures

  • Josep Bassaganya-Riera

Table of contents

  1. Front Matter
    Pages i-viii
  2. Pinyi Lu, David R. Bevan, Andrew Leber, Raquel Hontecillas, Nuria Tubau-Juni, Josep Bassaganya-Riera
    Pages 7-24
  3. Nuria Tubau-Juni, Raquel Hontecillas, Marion Ehrich, Andrew Leber, Victoria Zoccoli-Rodriguez, Josep Bassaganya-Riera
    Pages 25-40
  4. Meghna Verma, Raquel Hontecillas, Vida Abedi, Andrew Leber, Pinyi Lu, Nuria Tubau-Juni et al.
    Pages 41-56
  5. Ramin Zand, Vida Abedi, Raquel Hontecillas, Pinyi Lu, Nariman Noorbakhsh-Sabet, Meghna Verma et al.
    Pages 57-77
  6. Back Matter
    Pages 79-82

About this book

Introduction

Accelerated Path to Cures provides a transformative perspective on the power of combining advanced computational technologies, modeling, bioinformatics and machine learning approaches with nonclinical and clinical experimentation to accelerate drug development. This book discusses the application of advanced modeling technologies, from target identification and validation to nonclinical studies in animals to Phase 1-3 human clinical trials and post-approval monitoring, as alternative models of drug development. As a case of successful integration of computational modeling and drug development, we discuss the development of oral small molecule therapeutics for inflammatory bowel disease, from the application of docking studies to screening new chemical entities to the development of next-generation in silico human clinical trials from large-scale clinical data. Additionally, this book illustrates how modeling techniques, machine learning, and informatics can be utilized effectively at each stage of drug development to advance the progress towards predictive, preventive, personalized, precision medicine, and thus provide a successful framework for Path to Cures. 

Keywords

immunoinformatics Precision Medicine Path to Cures Computational Modeling Drug Development Clinical Trials

Editors and affiliations

  • Josep Bassaganya-Riera
    • 1
  1. 1.Nutritional Immunology and Molecular Medicine Laboratory, Biocomplexity Institute of Virginia TechBlacksburgUSA

Bibliographic information

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