Updates on Clostridium difficile in Europe

Advances in Microbiology, Infectious Diseases and Public Health Volume 8

  • Paola Mastrantonio
  • Maja Rupnik

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1050)

Also part of the Advances in Microbiology, Infectious Diseases and Public Health book sub series (AMIDPH, volume 1050)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Elena Reigadas Ramírez, Emilio Santiago Bouza
    Pages 1-12
  3. Camilla Wiuff, A-Lan Banks, Fidelma Fitzpatrick, Laura Cottom
    Pages 13-25
  4. Monique J. T. Crobach, Amoe Baktash, Nikolas Duszenko, Ed J. Kuijper
    Pages 27-44
  5. Jeanne Couturier, Kerrie Davies, Cécile Gateau, Frédéric Barbut
    Pages 45-58
  6. Sandra Janezic, Julian R. Garneau, Marc Monot
    Pages 59-75
  7. Panagiotis Papatheodorou, Holger Barth, Nigel Minton, Klaus Aktories
    Pages 77-96
  8. Claudia Vuotto, Gianfranco Donelli, Anthony Buckley, Caroline Chilton
    Pages 97-115
  9. Fidelma Fitzpatrick, Mairead Skally, Melissa Brady, Karen Burns, Christopher Rooney, Mark H. Wilcox
    Pages 117-135
  10. Patrizia Spigaglia, Paola Mastrantonio, Fabrizio Barbanti
    Pages 137-159
  11. Lorena Valdés-Varela, Miguel Gueimonde, Patricia Ruas-Madiedo
    Pages 161-176
  12. Marcello Maida, James Mcilroy, Gianluca Ianiro, Giovanni Cammarota
    Pages 177-195
  13. Jean-François Bruxelle, Séverine Péchiné, Anne Collignon
    Pages 197-225
  14. Cristina Rodriguez Diaz, Christian Seyboldt, Maja Rupnik
    Pages 227-243
  15. Paola Mastrantonio, Maja Rupnik
    Pages E1-E1
  16. Back Matter
    Pages 255-261

About this book


This book outlines the currently available clinical, epidemiological and experimental data on Clostridium difficile infection (CDI) with special emphasis on studies and results achieved in Europe. 

The incidence and severity of CDI has increased significantly over the last decade, and the book explains why C. difficile, recently reclassified as Clostridioides difficile, remains a significant challenge, also from economic perspective, to health care systems all over the world. The different reservoirs of this ubiquitous microorganism are reviewed as well as the different factors contributing to its virulence, such as toxins and biofilm formation. The rapid evolution of antibiotic resistance is clearly a concern and in a specific way can influence the CDI epidemiology. Additionally, new emerging strains and comparative genomics studies are discussed for their relevance from epidemiological and evolutionary point of view. 

The book also gives an overview on diagnostics, therapy and surveillance, all of which are still challenging. Therefore, a closer look is taken on the effect of probiotics as an alternative to antibiotics, for prevention and treatment of CDI. Fecal transplantation from healthy donors, passive immunotherapies and vaccines for patients with recurrences are also discussed in dedicated chapters. 

The book closes with a summary of the history and the achievements of the European Society of Clinical Microbiology and Infectious Diseases Study Group for Clostridium difficile (ESGCD) written by the current and past presidents of the Society. It is the aim of this book to raise awareness on CDI and to disseminate updated information on its prevention, diagnosis and treatment.


Clostridium difficile Clostridioides difficile nosocomial diarrhea microorganism pathogens infectious disease anaerobes Clostridium difficile infection CDI

Editors and affiliations

  • Paola Mastrantonio
    • 1
  • Maja Rupnik
    • 2
  1. 1.Former Research Director in the Department of Infectious DiseasesNational Institute of Health (ISS)RomeItaly
  2. 2.Department for Microbiological ResearchNational Laboratory of Health, Environment and Food (NLZOH)MariborSlovenia

Bibliographic information

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