© 2018

Drug Interactions in Infectious Diseases: Mechanisms and Models of Drug Interactions

  • Manjunath P. Pai
  • Jennifer J. Kiser
  • Paul O. Gubbins
  • Keith A. Rodvold

Part of the Infectious Disease book series (ID)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Manjunath P. Pai, Jennifer J. Kiser, Paul O. Gubbins, Keith A. Rodvold
    Pages 1-13
  3. David M. Burger, Lindsey H. M. te Brake, Rob E. Aarnoutse
    Pages 15-47
  4. Darren Michael Moss, Marco Siccardi, Catia Marzolini
    Pages 49-85
  5. Eric Wenzler, Kelly Sprandel-Harris, Keith A. Rodvold
    Pages 87-162
  6. Kerry B. Goralski, Matthew A. Ladda, Jenna O. McNeil
    Pages 163-204
  7. Surulivelrajan Mallayasamy, Scott R. Penzak
    Pages 205-242
  8. Grant T. Generaux
    Pages 243-257
  9. Anne N. Nafziger, Joseph S. Bertino Jr
    Pages 259-284
  10. David E. Nix, Keith Gallicano
    Pages 285-315
  11. Back Matter
    Pages 317-326

About this book


The 4th edition of Drug Interactions in Infectious Diseases is being split into two separate volumes – “Mechanisms and Models of Drug Interactions” and “Antimicrobial Drug Interactions”.

This volume, “Mechanisms and Models of Drug Interactions,” delivers a text that enhances clinical knowledge of the complex mechanisms, risks, and consequences of drug interactions associated with antimicrobials, infection, and inflammation.  The book provides a comprehensive review of basic clinical pharmacology with a focus on metabolism and transporter-mediated drug interactions. The chapters address materials that cannot be retrieved easily in the medical literature, including materials focused on the complex interrelationship of acute infection, inflammation, and the risk of drug interactions in the Drug-Cytokine chapter. The Food-Drug and Herb-Drug interactions chapters remain definitive resources. A new chapter on in vitro modeling of drug interactions is included along with updates on design and data analysis of clinical drug interaction studies. Authoritative discussion of models for regulatory decision-making on drug-drug interactions provides the necessary framework to aid antimicrobial drug development. This concise review of the mechanisms and models of drug interactions provides important insights to health care practitioners as well as scientists in drug development.


infectious disease drug interactions HIV HCV antimicrobials

Editors and affiliations

  • Manjunath P. Pai
    • 1
  • Jennifer J. Kiser
    • 2
  • Paul O. Gubbins
    • 3
  • Keith A. Rodvold
    • 4
  1. 1.College of PharmacyUniversity of MichiganAnn ArborUSA
  2. 2.Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical SciencesUniversity of ColoradoAuroraUSA
  3. 3.Division of Pharmacy Practice and AdministrationUMKC School of Pharmacy at MSUSpringfieldUSA
  4. 4.College of Pharmacy and MedicineUniversity of Illinois at ChicagoChicagoUSA

About the editors

Manjunath P. Pai, College of Pharmacy, University of Michigan, Ann Arbor, MI 

Jennifer J. Kiser, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO 

Paul O. Gubbins, School of Pharmacy, University of Missouri-Kansas City, Springfield, MO

Keith A. Rodvold, University of Illinois, College of Pharmacy and Medicine, Chicago, IL 

Bibliographic information

  • Book Title Drug Interactions in Infectious Diseases: Mechanisms and Models of Drug Interactions
  • Editors Manjunath P. Pai
    Jennifer J. Kiser
    Paul O. Gubbins
    Keith A. Rodvold
  • Series Title Infectious Disease
  • Series Abbreviated Title Infectious Disease
  • DOI
  • Copyright Information Springer International Publishing AG 2018
  • Publisher Name Humana Press, Cham
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-319-72421-8
  • Softcover ISBN 978-3-030-10198-5
  • eBook ISBN 978-3-319-72422-5
  • Edition Number 4
  • Number of Pages XVI, 326
  • Number of Illustrations 3 b/w illustrations, 5 illustrations in colour
  • Topics Pharmaceutical Sciences/Technology
    Infectious Diseases
  • Buy this book on publisher's site
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