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Cellular and Molecular Toxicology of Nanoparticles

  • Quaiser Saquib
  • Mohammad Faisal
  • Abdulaziz A. Al-Khedhairy
  • Abdulrahman A. Alatar

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1048)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Valeria De Matteis, Rosaria Rinaldi
    Pages 1-19
  3. Chloé Puisney, Armelle Baeza-Squiban, Sonja Boland
    Pages 21-36
  4. Swapnil Talkar, Sagar Dhoble, Anuradha Majumdar, Vandana Patravale
    Pages 37-57
  5. Mariusz Zuberek, Agnieszka Grzelak
    Pages 85-98
  6. Koyeli Girigoswami
    Pages 99-122
  7. Sourabh Dwivedi, Quaiser Saquib, Bilal Ahmad, Sabiha M. Ansari, Ameer Azam, Javed Musarrat
    Pages 143-161
  8. Quaiser Saquib, Maqsood A. Siddiqui, Javed Ahmad, Sabiha M. Ansari, Mohammad Faisal, Rizwan Wahab et al.
    Pages 163-174
  9. Saad Mohammad Ahsan, Chintalagiri Mohan Rao, Md. Faiz Ahmad
    Pages 175-198
  10. Blanca Laffon, Natalia Fernández-Bertólez, Carla Costa, Fátima Brandão, João Paulo Teixeira, Eduardo Pásaro et al.
    Pages 199-213
  11. Tiago Alves Jorge de Souza, Thiago Lopes Rocha, Leonardo Pereira Franchi
    Pages 215-226
  12. Lidia Strużyńska, Joanna Skalska
    Pages 227-250
  13. Lilian Rodrigues Rosa Souza, Veronica Santana da Silva, Leonardo Pereira Franchi, Tiago Alves Jorge de Souza
    Pages 251-262
  14. Mohd Ashraf Rather, Irfan Ahmad Bhat, Niti Sharma, Rupam Sharma
    Pages 263-284
  15. Svetlana Pleskova, Elza Mikheeva, Ekaterina Gornostaeva
    Pages 323-334
  16. Back Matter
    Pages 335-346

About this book

Introduction

This edited book is a compilation of findings on the molecular and cellular toxicity of nanoparticles (NPs) in animal cell, human cells, invertebrates. The varied selection of test models will provide better understanding about the horizon of NPs toxicity. Interaction of NPs with cells and its organelles can induce toxicological consequences, including transcriptional and translational alterations, DNA damage, cytotoxicity, oxidative stress, mitochondrial dysfunction and cell death. NPs can get internalized in cells through phagocytosis, macropinocytosis, receptor-mediated endocytosis and passive penetration, which can affect varied cell types.

Readers will be benefited with the compilations on basic and molecular facet of NPs toxicity. The chapters will provide a comprehensive information on the state-of-the-art methodologies. The application of toxicogenomic approaches, which is already established in nanotoxicology, has been given special consideration to unravel the toxicodynamics of nanomaterials. Among these approaches, the high-throughput RNA sequencing (RNA-Seq), which is able to build a complete map of transcriptome across different cell types and perturbations upon NPs exposure has been included. The readers are also introduced to the less studied topic on the adsorption of biomolecules (mainly proteins) on the NPs surface, constituting the so-called “biomolecular corona”.

The book has been designed for scientists engaged in NPs toxicity research. Nonetheless, it should be of interest to a variety of scientific disciplines including marine biology, environmental pollution, genetics, pharmacology, medicine, drug and food material sciences, consumer products. Also, the compilations will be of interest to the environmental watchdogs, federal regulators, risk assessors and the policy makers.

Keywords

Nanotoxicity Nanoparticles Genotoxicity Cell Death Apoptosis Transciptomics

Editors and affiliations

  • Quaiser Saquib
    • 1
  • Mohammad Faisal
    • 2
  • Abdulaziz A. Al-Khedhairy
    • 3
  • Abdulrahman A. Alatar
    • 4
  1. 1.Zoology Department, College of SciencesKing Saud UniversityRiyadhSaudi Arabia
  2. 2.Department of Botany and Microbiology, College of SciencesKing Saud UniversityRiyadhSaudi Arabia
  3. 3.Zoology Department, College of SciencesKing Saud UniversityRiyadhSaudi Arabia
  4. 4.Department of Botany and Microbiology, College of SciencesKing Saud UniversityRiyadhSaudi Arabia

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-72041-8
  • Copyright Information The Editor(s) (if applicable) and The Author(s) 2018
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-72040-1
  • Online ISBN 978-3-319-72041-8
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site
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