© 2020


Pathophysiology and Clinical Management

  • Benjamin Z. Leder
  • Marc N. Wein

Part of the Contemporary Endocrinology book series (COE)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Christina Vrahnas, Natalie A. Sims
    Pages 1-16
  3. Nicola Alesi, Julia F. Charles, Mary C. Nakamura
    Pages 17-41
  4. Jesus Delgado-Calle, Teresita Bellido
    Pages 43-69
  5. Roger Bouillon, Michaël R. Laurent
    Pages 71-87
  6. Paul Roschger, Barbara M. Misof, Klaus Klaushofer
    Pages 89-113
  7. René Rizzoli, Jean-Philippe Bonjour
    Pages 115-137
  8. Elaine W. Yu
    Pages 139-149
  9. Sabashini K. Ramchand, Joy N. Tsai
    Pages 151-167
  10. Matthew B. Greenblatt, Joy N. Tsai, Marc N. Wein
    Pages 169-184
  11. Jacqueline H. Cole, Marjolein C. H. van der Meulen
    Pages 185-209
  12. Belinda R. Beck, Kerri M. Winters-Stone
    Pages 211-238
  13. Jad G. Sfeir, Matthew T. Drake
    Pages 259-275
  14. Arthur C. Santora II, Anupa Sharma
    Pages 277-307
  15. Thomas J. Gardella
    Pages 323-347
  16. Gaia Tabacco, John P. Bilezikian
    Pages 349-362
  17. Roland Baron, Francesca Gori, Benjamin Z. Leder
    Pages 375-389

About this book


Completely revised and updated, and utilizing the most current evidence and practice guidelines for the treatment of osteoporosis, this comprehensive third edition discusses the basic aspects of bone metabolism, the pathophysiology of osteoporosis, current diagnostic techniques and medical treatment strategies. Osteoporosis is a common disorder that is prevalent in over 20 million Americans over the age of 60. One and a half million osteoporotic fractures occur in the United States every year, including 300,000 hip fractures. Mortality rates after hip fracture approach 25%, with another 50% of patients experiencing a major decrease in their prior level of independence and quality of life. Despite the wide prevalence and severe consequences of osteoporosis, it remains a disorder that is severely under-diagnosed and treated. In this context, specialists and primary care physicians alike are having increasing difficulty keeping up with the rapid changes to the field and incorporating these advances to clinical care.

In the years since the last edition of this book was published, the osteoporosis field has changed drastically. In addition to revising and updating existing chapters and removing a few that are no longer as relevant, new chapters discuss an advanced understanding of the cellular and molecular mechanisms underlying the disorder, the introduction of new diagnostic imaging techniques, a more nuanced appreciation of the risks and benefits of osteoporosis therapies, and the introduction of two new classes of osteoporosis medications. Following the format of the second edition, and including helpful key points at the opening of each chapter, this text will present a comprehensive overview of both the basic and clinical concepts relating to each topic, when appropriate. Chapter authors were chosen based on their high level of expertise and leadership in the field. Taken together, this text should thus be of great interest to physicians of multiple specialties, allied health professionals, as well as basic and clinical researchers.


Biomechanics of bone Biophosphonate Bone density scans Bone mass acquisition Bone morphology Bone turnover Calcium Denosumab Estrogen agonists/antagonists Estrogen and bone Glucocorticoid-induced Mineral assessment Osteoporosis Osteoporosis in men Osteoporosis related fractures Parathyroid hormone PTH/PTHrP analog Transplantation osteoporosis Vitamin D nutrition

Editors and affiliations

  • Benjamin Z. Leder
    • 1
  • Marc N. Wein
    • 2
  1. 1.Massachusetts General HospitalBostonUSA
  2. 2.Massachusetts General HospitalBostonUSA

About the editors

Benjamin Z. Leder, MD, Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

Marc N. Wein, MD, PhD, Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

Bibliographic information

  • Book Title Osteoporosis
  • Book Subtitle Pathophysiology and Clinical Management
  • Editors Benjamin Z. Leder
    Marc N. Wein
  • Series Title Contemporary Endocrinology
  • Series Abbreviated Title Contemporary Endocrinology
  • DOI
  • Copyright Information Springer Nature Switzerland AG 2020
  • Publisher Name Humana, Cham
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-319-69286-9
  • eBook ISBN 978-3-319-69287-6
  • Series ISSN 2523-3785
  • Series E-ISSN 2523-3793
  • Edition Number 3
  • Number of Pages XV, 516
  • Number of Illustrations 36 b/w illustrations, 46 illustrations in colour
  • Topics Endocrinology
    Primary Care Medicine
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology


“This book is an outstanding, comprehensive, evidence-based resource on osteoporosis pathophysiology and its recent therapeutics. … it is written in a clear and comprehensive manner. It is a very helpful resource for healthcare providers taking care of osteoporosis patients, basic and clinical researchers, and those training in endocrinology and rheumatology.” (Esraa Z Ismail, Doody's Book Reviews, November 6, 2020)