Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity

  • Akihiko Yoshimura

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 410)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Immune Checkpoint Cells

    1. Front Matter
      Pages 1-1
    2. Yosuke Togashi, Hiroyoshi Nishikawa
      Pages 3-27
    3. Keishi Fujio, Kazuhiko Yamamoto, Tomohisa Okamura
      Pages 29-45
    4. Katsuaki Sato, Tomofumi Uto, Tomohiro Fukaya, Hideaki Takagi
      Pages 47-71
  3. Extracellular Immune Checkpoint Molecules

    1. Front Matter
      Pages 73-73
    2. Kenji Chamoto, Muna Al-Habsi, Tasuku Honjo
      Pages 75-97
    3. Nicole Joller, Vijay K. Kuchroo
      Pages 127-156
  4. Intracelluar Immune Checkpoint Molecules

    1. Front Matter
      Pages 157-157
    2. Subburaj Ilangumaran, Diwakar Bobbala, Sheela Ramanathan
      Pages 159-189
    3. Claudia Penafuerte, Luis Alberto Perez-Quintero, Valerie Vinette, Teri Hatzihristidis, Michel L. Tremblay
      Pages 191-214
    4. Peng Zeng, Jieyu Ma, Runqing Yang, Yun-Cai Liu
      Pages 215-248
    5. Cheng-Jang Wu, Li-Fan Lu
      Pages 249-267
  5. Kenji Chamoto, Muna Al-Habsi, Tasuku Honjo
    Pages E1-E1

About this book


This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to “molecules and cells that negatively regulate T-cell activation”. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases.

Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike.


Anti-tumor immune response Tumor immune microenvironment Regulatory T cells PD-1 Autoimmune disease Immunoregulation Cancer therapy Regulatory dendritic cells Extracellular immune checkpoint molecules Intracellular immune checkpoint molecules CTLA-4 Tim-3 Lag-3 TIGIT SOCS1 Tregs

Editors and affiliations

  • Akihiko Yoshimura
    • 1
  1. 1.Department of Microbiology and ImmunologyKeio University School of MedicineTokyoJapan

Bibliographic information

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