Pediatric Obesity

Etiology, Pathogenesis and Treatment

  • Michael S. Freemark

Part of the Contemporary Endocrinology book series (COE)

Table of contents

  1. Front Matter
    Pages i-xxv
  2. The Obesity Epidemic: A Global Perspective

  3. Hormonal and Metabolic Control of Appetite, Fat Deposition, and Energy Expenditure

    1. Front Matter
      Pages 25-25
    2. Belma Haliloglu, Abdullah Bereket
      Pages 27-42
    3. Laura C. Page, Mark D. Miller, David D’Alessio, Jenny Tong
      Pages 43-61
    4. Anita L. Kozyrskyj, Hein Min Tun, Sarah L. Bridgman
      Pages 63-78
  4. Adipocyte Development and Function in Obesity and Insulin Resistance

    1. Front Matter
      Pages 79-79
    2. Pamela Fischer-Posovszky, Julian Roos, Verena Zoller, Martin Wabitsch
      Pages 81-93
    3. Antje Körner, Wieland Kiess, Kathrin Landgraf
      Pages 95-115
    4. Michael Freemark, Sheila Collins
      Pages 117-132
  5. The Genetics of Childhood Obesity

    1. Front Matter
      Pages 133-133
    2. Marie Pigeyre, David Meyre
      Pages 135-152
    3. Krystal A. Irizarry, Andrea M. Haqq
      Pages 153-182
    4. Anke Hinney, Johanna Giuranna
      Pages 183-202
  6. Pre- and Peri-natal Determinants of Childhood Obesity

    1. Front Matter
      Pages 203-203
    2. Jenna Hollis, Hazel Inskip, Siân Robinson
      Pages 205-213
    3. Ken K. Ong
      Pages 215-227
    4. Dana Dabelea, Katherine A. Sauder
      Pages 229-242
    5. Leonardo Trasande, Bruce Blumberg
      Pages 243-253
  7. The Roles of Diet and Energy Expenditure in Obesity Pathogenesis and Complications

    1. Front Matter
      Pages 255-255
    2. Megan H. Pesch, Julie C. Lumeng
      Pages 257-270
    3. Megan L. Gow, Mandy Ho, Natalie B. Lister, Sarah P. Garnett
      Pages 271-286
    4. Gina Segovia-Siapco, Sarah Jung, Joan Sabaté
      Pages 287-303
    5. Lorraine Lanningham-Foster, James A. Levine
      Pages 305-319
  8. Metabolic Complications of Childhood Obesity

    1. Front Matter
      Pages 321-321
    2. Pinar Gumus Balikcioglu, Christopher B. Newgard
      Pages 343-361
    3. Yazan Alwarawrah, Nancie J. MacIver
      Pages 363-378
    4. Orit Pinhas-Hamiel, Philip S. Zeitler, Megan M. Kelsey
      Pages 393-418
    5. Della Corte Claudia, Antonella Mosca, Arianna Alterio, Donatella Comparcola, Francesca Ferretti, Valerio Nobili
      Pages 451-462
    6. Tracy E. Hunley, Vance L. Albaugh, Valentina Kon
      Pages 463-495
    7. Annelies Van Eyck, Stijn Verhulst
      Pages 497-509
    8. Costan G. Magnussen, Brooklyn J. Fraser, Olli T. Raitakari
      Pages 511-526
    9. Amy S. Shah, Elaine M. Urbina
      Pages 527-538
    10. Dawn M. Eichen, Sara Appleton-Knapp, Kerri N. Boutelle
      Pages 539-551
  9. Treatment of Childhood Obesity: Lifestyle Intervention

    1. Front Matter
      Pages 553-553
    2. Denise E. Wilfley, Katherine N. Balantekin
      Pages 555-567
    3. David Thivel, Grace O’Malley, Julien Aucouturier
      Pages 569-587
    4. Joel Gittelsohn, Sohyun Park
      Pages 589-610
  10. Pharmacotherapy and Bariatric Surgery for Obesity and Co-morbidities

  11. Challenges to Long-Term Success

    1. Front Matter
      Pages 683-683

About this book


This second edition of Freemark’s text embodies all of the strengths of the original work but is deeper and broader in scope, with new chapters on emerging themes including metabolomics, genomics, and the roles of gastrointestinal hormones, the microbiome, brown adipose tissue, and endocrine disruptors in the pathogenesis of childhood obesity. Reviews of the effects of weight excess on cognitive performance and immune function complement detailed analyses of the biochemical and molecular pathways controlling the development of childhood adiposity and metabolic disease. Critical assessments of nutritional interventions (including new chapters on infant feeding practices and vegetarian diets) and superb reviews of behavioral counseling, pharmacotherapy, and bariatric surgery provide practical guidance for the management of overweight children. Penetrating analyses of the obesity epidemic in its social, cultural, economic, and political contexts highlight challenges and opportunities for obesity prevention and community action. The perspective is international in scope and reflects the expertise and experience of many of the leading figures in the field.

Comprehensive and up-to-date, this new edition of Pediatric Obesity: Etiology, Pathogenesis and Treatment will be an invaluable guide for all healthcare providers and policy makers concerned with the evaluation and care of children with nutritional and metabolic disease and with the societal implications of the obesity epidemic.


Adipocyte Gastrointestinal hormones Lifestyle intervention Metabolic complications Microbiome Monogenic obesity Neuroendocrine control Pediatric obesity Polygenic obesity Syndromic obesity Type 2 diabetes Weight gain

Editors and affiliations

  • Michael S. Freemark
    • 1
  1. 1.Duke University School of Medicine DurhamUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG 2018
  • Publisher Name Humana Press, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-68191-7
  • Online ISBN 978-3-319-68192-4
  • Series Print ISSN 2523-3785
  • Series Online ISSN 2523-3793
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology