Cellular and Molecular Approaches to Regeneration and Repair

  • Paul A. Lapchak
  • John H. Zhang

Part of the Springer Series in Translational Stroke Research book series (SSTSR)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Stem Cells

    1. Front Matter
      Pages 1-1
    2. Pascal Gervois, Yörg Dillen, Tim Vangansewinkel, Petra Hilkens, Ronald B. Driesen, Greet Merckx et al.
      Pages 21-45
    3. Aurel Popa-Wagner, Mario Di Napoli
      Pages 47-71
    4. Monika Rabenstein, Maria Adele Rueger
      Pages 101-112
    5. Lukas Andereggen, Raluca Reitmeir, Stefano Di Santo, Raphael Guzman, Hans R. Widmer, Serge Marbacher et al.
      Pages 129-152
    6. Hung Nguyen, M. Grant Liska, Marci G. Crowley, Cesario V. Borlongan
      Pages 153-180
    7. Yi Shen, Poornima Venkat, Michael Chopp, Jieli Chen
      Pages 217-237
    8. Johanna Gutierrez-Vargas, Rafael Posada-Duque, Gloria Patricia Cardona-Gómez
      Pages 259-280
    9. Eric S. Sussman, Gary K. Steinberg
      Pages 281-292
  3. Exosomes-miRNA

    1. Front Matter
      Pages 309-309
    2. Benjamin Buller, Michael Chopp, Zheng Gang Zhang
      Pages 311-324
    3. Ji Bihl, Jinju Wang, Xiaotang Ma, Yi Yang, Bin Zhao, Yanfang Chen
      Pages 325-361
  4. Neuronal Environment, Plasticity and Repair Mechanisms

    1. Front Matter
      Pages 363-363
    2. Max O. Krucoff, Stephen C. Harward, Shervin Rahimpour, Keith Dombrowski, Erik F. Hauck, Shivanand P. Lad et al.
      Pages 365-382
    3. Norihito Shimamura, Takeshi Katagai, Masato Naraoka, Hiroki Ohkuma
      Pages 383-396
    4. A-Hyun Cho, Neethu Michael, David H. Cribbs, Mark J. Fisher
      Pages 481-490
    5. Julia V. Cramer, Arthur Liesz
      Pages 491-507
    6. Anna Stokowska, Marcela Pekna
      Pages 521-541

About this book


This book discusses recent advances in the field of translational stroke research. The editors have designed the book to provide new insight into the importance of regeneration and repair mechanisms for stroke victims. The editors have brought together a talented group of international stroke researchers and clinicians to contribute to this volume, which is written for students, researchers and physicians in biotechnology, neurosciences, neurology, neuroradiology and neurosurgery.

Throughout the world, stroke is still a leading cause of mortality and morbidity; there are 152,000 strokes in the United Kingdom, 62,000 in Canada, and approximately 15 million people worldwide. Large communities of stroke survivors are eagerly awaiting scientific advances in translational stroke research related to regeneration and recovery of function that would offer new therapeutics for rehabilitation and regeneration utilizing novel stem cell and molecular-based approaches. This volume will allow the reader to understand the future of stroke treatment from its inception in the laboratory through to clinical trial design. The reader will learn about the recent advances made in these areas related to basic and applied stroke research and their translational potential.

Dr. Paul A. Lapchak is Professor of Neurology and Director of Translational Research in the Departments of Neurology & Neurosurgery at Cedars-Sinai Medical Center in Los Angeles CA, USA. Dr. Lapchak is an internationally recognized expert conducting translational drug development research for ischemic and hemorrhagic stroke.

Dr. John H. Zhang is Professor of Anesthesiology, Neurosurgery, Neurology, and Physiology, and Director, Center for Neuroscience Research at Loma Linda University School of Medicine, Loma Linda, CA, USA. Dr. Zhang is an internationally recognized expert working on drug development for hemorrhagic stroke.


stroke regeneration exosomes stem cell therapy neurotrophic molecular

Editors and affiliations

  • Paul A. Lapchak
    • 1
  • John H. Zhang
    • 2
  1. 1.Department of Neurology & NeurosurgeryCedars-Sinai Medical Center, AHSPLos AngelesUSA
  2. 2.Department of PhysiologyLoma Linda UniversityLoma LindaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-66678-5
  • Online ISBN 978-3-319-66679-2
  • Series Print ISSN 2363-958X
  • Series Online ISSN 2363-9598
  • Buy this book on publisher's site
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