© 2017

Understanding the Gut-Bone Signaling Axis

Mechanisms and Therapeutic Implications

  • Laura R. McCabe
  • Narayanan Parameswaran


  • The first book to combine current knowledge on gut and bone research

  • Authored by international experts in the field

  • Reviews exhaustively the key recent research regarding everything from signaling pathways to pathologies to intestinal environments


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1033)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Gut-Bone Signaling Pathways

    1. Front Matter
      Pages 1-1
    2. Sylvia Christakos, Vaishali Veldurthy, Nishant Patel, Ran Wei
      Pages 3-12
    3. Walter Ramsey, Carlos M. Isales
      Pages 13-33
    4. Brigitte Lavoie, Jane B. Lian, Gary M. Mawe
      Pages 35-46
    5. Darin Quach, Robert A. Britton
      Pages 47-58
    6. Fraser L. Collins, Jonathan D. Schepper, Naiomy Deliz Rios-Arce, Michael D. Steury, Ho Jun Kang, Heather Mallin et al.
      Pages 59-94
  3. Gut Pathologies and Bone Health

    1. Front Matter
      Pages 95-95
    2. Alice M. Kitay, John P. Geibel
      Pages 97-131
    3. Francisco A. Sylvester
      Pages 133-150
    4. Naiomy Deliz Rios-Arce, Fraser L. Collins, Jonathan D. Schepper, Michael D. Steury, Sandi Raehtz, Heather Mallin et al.
      Pages 151-183
  4. Modulation of Gut Microbiota to Support Bone Health

    1. Front Matter
      Pages 199-199
    2. Corrie M. Whisner, Connie M. Weaver
      Pages 201-224
    3. Jonathan D. Schepper, Regina Irwin, Jun Kang, Kevin Dagenais, Tristan Lemon, Ally Shinouskis et al.
      Pages 225-247
    4. C. J. Hernandez
      Pages 249-270
  5. Back Matter
    Pages 271-277

About this book


This is the first book compiling current research on the gut-bone signaling axis and its implications in the pathophysiology of GI and bone diseases. Rather than focusing on a single mechanism, this book provides the reader with a broad view on gut-bone signaling and the most up-to-date information in this rapidly growing area.  The volume is also unique in that it looks at what is known about GI diseases affecting bone and then examines the role of the microbiome and its modulation by pre and probiotics to treat bone disease, placing this topic within the context of gut-bone signaling pathways. Understanding the Gut-Bone Signaling Axis will thus provide an understanding of how various therapies could be applied to this area.


GI Intestinal Microbiota pathogens pathways pharmacology

Editors and affiliations

  • Laura R. McCabe
    • 1
  • Narayanan Parameswaran
    • 2
  1. 1.Department of Physiology and Department of Radiology Biomedical Imaging Research CentreMichigan State UniversityEast LansingUSA
  2. 2.Comparative Medicine and Integrative Biology ProgramEast LansingUSA

About the editors

Laura R. McCabe, PhD is the Director of the Molecular Metabolism and Disease Program at Michigan State University. Dr. McCabe’s research focuses on understanding the mechanisms regulating bone cell (osteoblast) differentiation and bone formation. Her lab is taking an integrative approach to examine bone adaptation to diseases (such as diabetes and inflammatory bowel disease) and is working toward identifying mechanisms regulating bone formation by osteoblasts.  Approaches include examination of transcription factor activity, intracellular signaling pathway activation, stem cell lineage selection, apoptosis, metabolism and immune system contributions utilizing cell culture systems, animal models and human imaging. Dr. McCabe’s lab is also developing therapeutics to target identified mechanisms and pathways to increase bone formation.

Bibliographic information

  • Book Title Understanding the Gut-Bone Signaling Axis
  • Book Subtitle Mechanisms and Therapeutic Implications
  • Editors Laura R. McCabe
    Narayanan Parameswaran
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-66651-8
  • Softcover ISBN 978-3-319-88293-2
  • eBook ISBN 978-3-319-66653-2
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages XIII, 277
  • Number of Illustrations 7 b/w illustrations, 29 illustrations in colour
  • Topics Endocrinology
    Human Physiology
    Systems Biology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology