IgM and Its Receptors and Binding Proteins

  • Hiromi Kubagawa
  • Peter D. Burrows

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 408)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Hiromi Kubagawa, Christopher M. Skopnik, Jakob Zimmermann, Pawel Durek, Hyun-Dong Chang, Esther Yoo et al.
    Pages 25-45
  3. Anna Sörman, Birgitta Heyman
    Pages 67-87

About this book


This volume reviews the current state of research on the IgM antibody and its multiple receptors and binding proteins. Interactions of the IgM ligands with these molecules are important for protection against infections as a first line of defense, as well as for regulation of immune responses to pathogens and self-antigens. The book includes up-to-date information on: (i) the phylogeny of three IgM-binding receptors [polymeric Ig receptor (pIgR), Fc receptor for both IgA and IgM (Fcα/µR), and Fc receptor for IgM only (FcµR)]; (ii) the lymphocyte-restricted distribution and unique ligand-binding activity of FcµR; (iii) the definition and potential function of Fc receptor-like molecule A (FCRLA) as a resident endoplasmic reticulum protein that binds IgM, but also IgG and IgA; (iv) IgM antibody-mediated enhancement of humoral immune responses, highlighting the importance of complement and its receptors, (v) the numerous important roles of IgM natural antibodies in regulation of inflammation. It is an invaluable resource for researchers and clinicians alike.


Fc-receptor evolution Antibody response Natural antibodies pIgR IgA Fcα/µR Fc receptor FcµR FCRLA

Editors and affiliations

  • Hiromi Kubagawa
    • 1
  • Peter D. Burrows
    • 2
  1. 1.Deutsches RheumaforschungszentrumBerlinGermany
  2. 2.Department of MicrobiologyUniversity of Alabama at BirminghamBirminghamUSA

Bibliographic information

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