Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control

  • Sebastien Gagneux

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1019)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Philip Supply, Roland Brosch
    Pages 27-41
  3. Matthias Merker, Thomas A. Kohl, Stefan Niemann, Philip Supply
    Pages 43-78
  4. Iñaki Comas
    Pages 79-93
  5. Dorothy Yeboah-Manu, Bouke C. de Jong, Florian Gehre
    Pages 117-133
  6. Abdallah M. Abdallah, Marcel A. Behr
    Pages 155-169
  7. Giovanni Delogu, Michael J. Brennan, Riccardo Manganelli
    Pages 191-207
  8. Anna S. Dean, Helen Cox, Matteo Zignol
    Pages 209-220
  9. Daniela M. Cirillo, Paolo Miotto, Enrico Tortoli
    Pages 221-246
  10. Digby F. Warner, Jeremy M. Rock, Sarah M. Fortune, Valerie Mizrahi
    Pages 247-262
  11. Sonia Borrell, Andrej Trauner
    Pages 263-279
  12. Jūlija Pečerska, James Wood, Mark M. Tanaka, Tanja Stadler
    Pages 281-307
  13. Back Matter
    Pages 309-314

About this book


Until about 10 years ago, the general view in the field was that Mycobacterium tuberculosis, the causative agent of human tuberculosis was a “clone” with insufficient natural sequence variation between clinical strains to be considered biologically and epidemiologically “relevant”. This view has now changed quite dramatically thanks to the –omics revolution, particularly the advent of next generation DNA sequencing. Large-scale comparative genomic studies over the last few years have revealed that M. tuberculosis clinical strains are more genetically diverse than appreciated previously. Moreover, an increasing number of experimental and epidemiological studies are showing that this genetic diversity also translates into important phenotypic variation. Taken together, these findings have led to a paradigm shift, such that currently phylogenetic diversity among M. tuberculosis clinical strains is being considered in the development of new tools to combat tuberculosis. 
The purpose of this book is to bring together a series of contributions from some of the most influential groups working on various aspects of M. tuberculosis diversity, and which through their work have contributed to the this paradigm shift. This includes authors focusing on the evolution of M. tuberculosis in relation to other members of the M. tuberculosis complex adapted to animals, the co-evolution between M. tuberculosis and humans, the phenotypic consequences of strains diversity both from an experimental and epidemiological point of view, the ecology and evolution of drug resistant tuberculosis, the diversity and evolution of the BCG vaccine strains, and the use of mathematical modelling to study strain diversity and drug resistance in human tuberculosis. No such book has ever been published, and given the paradigm shift described above, this book will be a valuable resource both for established researchers as well as new scientists, clinicians and public health officials joining the growing field of tuberculosis research.


Mycobacterium africanum Mycobacterium canettii Mycobacterium tuberculosis epidemiology strain variation

Editors and affiliations

  • Sebastien Gagneux
    • 1
  1. 1.Swiss Tropical & Public Health InstituteUniversity of BaselBaselSwitzerland

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