© 2018

Acute Promyelocytic Leukemia

A Clinical Guide

  • Oussama Abla
  • Francesco Lo Coco
  • Miguel A. Sanz

Table of contents

  1. Front Matter
    Pages i-xii
  2. Laurent Degos
    Pages 1-16
  3. Ramy Rahmé, Cécile Esnault, Hugues de Thé
    Pages 17-27
  4. Thalia Vlachou, Giulia De Conti, Anna Giulia Sanarico, Pier Giuseppe Pelicci
    Pages 29-40
  5. Lourdes Mendez, Ming Chen, Pier Paolo Pandolfi
    Pages 41-53
  6. Anna Falanga, Laura Russo, Pau Montesinos
    Pages 55-70
  7. Sören Lehmann
    Pages 71-86
  8. Javier de la Serna, Pau Montesinos, Miguel A. Sanz
    Pages 87-98
  9. Aaron D. Goldberg, Martin S. Tallman
    Pages 99-112
  10. Mary-Elizabeth M. Percival, Elihu H. Estey
    Pages 133-151
  11. Laura Cicconi, Eva Barragàn
    Pages 153-161
  12. Eva Lengfelder
    Pages 163-170
  13. Jaime Sanz, Miguel A. Sanz
    Pages 171-177
  14. Matthew A. Kutny, Anna Maria Testi
    Pages 179-195
  15. Ramy Rahmé, Lionel Adès, Pierre Fenaux
    Pages 197-201
  16. Massimo Breccia, Gloria Iacoboni, Miguel A. Sanz
    Pages 203-210
  17. Luisa Corrêa de Araújo Koury, Raul Ribeiro, Eduardo M. Rego
    Pages 211-216
  18. Kristen Pettit, Richard A. Larson
    Pages 231-242

About this book


This book provides a comprehensive overview on the clinical issues and biology of acute promyelocytic leukemia (APL) and on the molecular mechanisms of targeted therapy with ATRA and ATO. The text covers major topics such as the pathophysiology of APL coagulopathy, biologic and clinical differences between children and adults with APL, and the role of minimal residual disease monitoring. Additionally, the book summarizes historical, current, and future treatment strategies in both adults and children, while highlighting the most recent therapeutic recommendations for relapsed disease and the evolving indications for autologous and allogeneic stem cell transplant. This volume also features chapters focusing on secondary APL and therapy, late effects, rare presentations such as APL in the elderly and during pregnancy, and rare APL variants that may represent therapeutic challenges.

Written by top experts in the field, Acute Promyelocytic Leukemia: A Clinical Guide is a valuable resource for clinicians and researchers who treat and investigate this disease in children and adults.


APL Animal Models APL coagulopathy ATRA-ATO MRD monitoring autologous stem cell transplant allogeneic stem cell transplant

Editors and affiliations

  • Oussama Abla
    • 1
  • Francesco Lo Coco
    • 2
  • Miguel A. Sanz
    • 3
  1. 1.Division of Hematology/OncologyThe Hospital for Sick Children and University of TorontoTorontoCanada
  2. 2.Department of HematologyUniversity of Tor VergataRomeItaly
  3. 3.Department of MedicineHospital Universitari i Politecnic La Fe, University of ValenciaValenciaSpain

About the editors

Oussama Abla, MD

The Hospital for Sick Children and University of Toronto

Division of Hematology/Oncology

Toronto, ON



Francesco Lo-Coco, MD

Professor of Hematology

University of Tor Vergata




Miguel A. Sanz, MD

Centro de Investigación Biomédica en Red de Cáncer



Bibliographic information

  • Book Title Acute Promyelocytic Leukemia
  • Book Subtitle A Clinical Guide
  • Editors Oussama Abla
    Francesco Lo Coco
    Miguel A. Sanz
  • DOI
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-319-64256-7
  • Softcover ISBN 978-3-030-09713-4
  • eBook ISBN 978-3-319-64257-4
  • Edition Number 1
  • Number of Pages XII, 274
  • Number of Illustrations 10 b/w illustrations, 29 illustrations in colour
  • Topics Hematology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Oncology & Hematology


“This is a clinical guide to acute promyelocytic leukemia or APL, and it is the first book dedicated entirely to APL. Starting with an engaging historical account, the book provides a comprehensive overview of the clinical and basic aspects of APL, once regarded as the most fatal type of acute myeloid leukemia, but now considered the most curable. … general practitioners and trainees also will find this book worth exploring … .” (Ravi Salgia, Doody's Book Reviews, January 04, 2019)