© 2017

Precision Medicine, CRISPR, and Genome Engineering

Moving from Association to Biology and Therapeutics

  • Stephen H. Tsang


  • Timely State-of-the-science on CRISPR and gene editing, an exciting and controversial frontier in regenerative medicine

  • Contributed by top experts in this rapidly-evolving field

  • One of the first books to connect genetically modified foods to this area


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1016)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Introduction to the CRISPR Revolution

    1. Front Matter
      Pages 1-1
    2. James E. DiCarlo, Anurag Deeconda, Stephen H. Tsang
      Pages 3-27
  3. CRISPR in Model Systems

    1. Front Matter
      Pages 43-43
    2. Anindya Bandyopadhyay, Shamik Mazumdar, Xiaojia Yin, William Paul Quick
      Pages 101-120
  4. The Future of CRISPR

    1. Front Matter
      Pages 121-121
    2. Xinyi Guo, Poonam Chitale, Neville E. Sanjana
      Pages 123-145
    3. Galaxy Y. Cho, Sally Justus, Jesse D. Sengillo, Stephen H. Tsang
      Pages 147-155
    4. Soren H. Hough, Ayokunmi Ajetunmobi
      Pages 157-178

About this book


This book presents descriptive overviews of gene editing strategies across multiple species while also offering in-depth insight on complex cases of application in the field of tissue engineering and regenerative medicine.  Chapters feature contributions from leaders in stem cell therapy and biology, providing a comprehensive view of the application of gene therapy in numerous fields with an emphasis on ophthalmology, stem cells, and agriculture. The book also highlights recent major technological advances, including ZFN, TALEN, and CRISPR. Precision Medicine, CRISPR, and Genome Engineering is part of the highly successful Advances in Experimental Medicine and Biology series. It is an indispensable resource for researchers and students in genetics as well as clinicians. 


Genetically Modified gRNA Design Ophthalmologic Disease ZFN TALEN

Editors and affiliations

  • Stephen H. Tsang
    • 1
  1. 1.Departments of Ophthalmology, Pathology & Cell Biology and Biomedical EngineeringInstitute of Human Nutrition, Columbia Stem Cell Initiative, Herbert Irving Comprehensive Cancer Center, Graduate Program in Neurobiology & Behavior, Columbia UniversityNew YorkUSA

About the editors

For years, Stephen Tsang has been culturing embryonic stem (ES) cells and created the first mouse model for a recessive form of retinitis pigmentosa by applying homologous recombination to ES cell technology. Two elements define his laboratory. First, by leveraging his genetics clinical practice, in which over 1000 retinal patients are cared for, he brings an array of clinical resources to his research, including stem cells and live imaging data. Second, he and his students are recognized authorities in a broad array of state-of-the-art technologies. Most recently, he was invited as a Moderator for the Gene Editing/Rewriting the Genome session during the 65th American Society of Human Genetics Annual Meeting.

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