© 2018

Chromatin Regulation of Early Embryonic Lineage Specification

  • Jason Knott
  • Keith Latham


  • Examines the roles of early acting chromatin regulators in ICM and TE formation

  • Explores the role of RHOA subfamily of small GTPases and RHO-associated coiled-coil kinases

  • Provides an overview on the transcriptional and epigenetic mechanisms that mediate PE lineage formation and XEN cell self-renewal


Part of the Advances in Anatomy, Embryology and Cell Biology book series (ADVSANAT, volume 229)

About this book


Five leaders in the field of mammalian preimplantation embryo development provide their own perspectives on key molecular and cellular processes that mediate lineage formation during the first week of life. The first cell-fate decision involves the formation of the pluripotent inner cell mass (ICM) and extraembryonic trophectoderm (TE). The second cell-fate choice encompasses the transformation of ICM into extraembryonic primitive endoderm (PE) and pluripotent epiblast. The processes, which occur during the period of preimplantation development, serve as the foundation for subsequent developmental events such as implantation, placentation, and gastrulation. The mechanisms that regulate them are complex and involve many different factors operating spatially and temporally over several days to modulate embryonic chromatin structure, impose cellular polarity, and direct distinct gene expression programs in the first cell lineages. 


extraembryonic primitive endoderm pluripotent epiblast embryonic chromatin structure CHD1 CHD4 H3R26me SOX2-DNA

Editors and affiliations

  • Jason Knott
    • 1
  • Keith Latham
    • 2
  1. 1.Department of Animal ScienceMichigan State UniversityEast LansingUSA
  2. 2.Department of Animal ScienceMichigan State UniversityEast LansingUSA

About the editors

Dr. Jason Knott is a reproductive and developmental biologist with fifteen years of experience in mammalian embryology and stem cell biology. His research program is focused on elucidating chromatin based mechanisms that regulate gene expression programs and cell-fate determination in preimplantation embryos and embryonic stem cells. His current research focus is on understanding transcriptional and epigenetic mechanisms that govern cell polarity, pluripotency, trophoblast lineage formation, and trophoblast lineage differentiation in mice, humans, and cattle. 

Dr. Keith Latham is a developmental biologist with nearly three decades of experience in mammalian embryology.  His research encompasses epigenetics and imprinting in the early embryo, transcriptional control, translational control, determinants of oocyte quality, and mechanisms underlying meiotic spindle formation and function.  His research combines the use of diver
se mouse strains, molecular assays applicable to the single cell level, and embryo micromanipulation including different forms of nuclear transfer.

Bibliographic information

  • Book Title Chromatin Regulation of Early Embryonic Lineage Specification
  • Editors Jason Knott
    Keith Latham
  • Series Title Advances in Anatomy, Embryology and Cell Biology
  • Series Abbreviated Title Advs Anatomy
  • DOI
  • Copyright Information Springer International Publishing AG 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Softcover ISBN 978-3-319-63186-8
  • eBook ISBN 978-3-319-63187-5
  • Series ISSN 0301-5556
  • Series E-ISSN 2192-7065
  • Edition Number 1
  • Number of Pages VII, 78
  • Number of Illustrations 0 b/w illustrations, 16 illustrations in colour
  • Topics Human Genetics
    Cell Biology
    Human Physiology
  • Buy this book on publisher's site
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