© 2018

Atlas of Thyroid and Neuroendocrine Tumor Markers

  • Luca Giovanella

Table of contents

  1. Front Matter
    Pages i-xii
  2. Pathology and Pathobiology

    1. Front Matter
      Pages 1-1
    2. Esther Diana Rossi, Guido Fadda
      Pages 3-12
  3. Differentiated Thyroid Cancer

    1. Front Matter
      Pages 49-49
    2. Luca Giovanella, Federica D’Aurizio, Renato Tozzoli, Camilla Schalin-Jantti, Ulla Feldt-Rasmussen
      Pages 65-91
    3. Cosimo Durante, Francesca Rosignolo, Marialuisa Sponziello, Antonella Verrienti, Sebastiano Filetti
      Pages 93-105
    4. Thomas Winkens, Katharina Pachmann, Martin Freesmeyer
      Pages 107-115
  4. Medullary Thyroid Carcinoma

    1. Front Matter
      Pages 117-117
    2. M. Alevizaki, K. Saltiki, G. Simeakis, T. Pappa
      Pages 119-132
    3. Giuseppe Costante, Yassine Lalami, Christiane Jungels, Ahmad Awada
      Pages 133-150
    4. Pierpaolo Trimboli, Alicia Algeciras-Schimnich, Luca Giovanella
      Pages 151-157
  5. Aggressive and Rare Thyroid Carcinoma

    1. Front Matter
      Pages 159-159
    2. Massimo Salvatori, Claudio Altini, Luca Zagaria, Alfonso Verrillo, Germano Perotti
      Pages 161-173
    3. Luca Giovanella, Federica D’Aurizio, Renato Tozzoli
      Pages 175-189
  6. Thyroid Biomarkers on Fine-Needle Washouts

    1. Front Matter
      Pages 191-191
    2. Pierpaolo Trimboli, Luca Giovanella
      Pages 193-200
  7. Neuroendocrine Tumors

    1. Front Matter
      Pages 201-201

About this book


This book highlights the increase in thyroid tumors and NET and demonstrates the growing importance of circulating markers in diagnosis as well as treatment and follow-up. Dramatic technical improvements have heightened the clinical impact of well-established, conventional biochemical markers. In addition, more recent genetic and molecular approaches have provided innovative molecular markers. In this context, effective communication between clinicians and laboratory physicians/scientists is essential in allowing all those involved to fully profit from these exciting advances.  In this comprehensive, up-to-date book, authors from different laboratory and clinical areas link laboratory and clinical topics. Analytical problems such as interferences, false-negative and false-positive results are discussed in depth, and flow-charts offer insights into identifying and avoiding them. Illustrated clinical cases detail the clinical role and limitations of different tumor markers. Lastly, it explores health technology assessment and economic issues.

This is a valuable resource for endocrinologists, oncologists, nuclear medicine physicians, scientists and technologists who want to keep abreast of the latest developments.


Biomarkers Calcitonin Chromogranin-A Thyroglobulin miRNA

Editors and affiliations

  • Luca Giovanella
    • 1
  1. 1.Nuclear Medicine and Thyroid CentreOncology Institute of Southern SwitzerlandBellinzonaSwitzerland

About the editors

Luca Giovanella completed his doctoral thesis at the University of Pavia (I) Medical School of in 1991. He subsequently obtained his postgraduate degrees in Nuclear Medicine (1995) and Endocrinology (2000) at the University of Milan (I) and was awarded an executive masters degree in Health Organisation and Human Resources Management (2000) by the Politecnico Universitario of Milan (I). He was a consultant at the University Hospital “Fondazione Macchi” of Varese (I) Department of Nuclear Medicine from 1993 to 2002, and he also chaired the Thyroid Unit and the Laboratory for Endocrinology from 1995 to 2002. Since 2003 he has been the Director of the Department of Nuclear Medicine-PET/CT and the Competence Centre for Thyroid Diseases at the Oncology Institute of Southern Switzerland (IOSI) in Bellinzona and Lugano. He also serves as a scientific advisor for the Department of Clinical Chemistry and Laboratory Medicine at Ente Ospedaliero Cantonale in Bellinzona. From 2008 to 2014 he has been a “Privat-Dozent” (PD) and since 2015 he is a "Titular Professor" at the University of Zürich’s Institute of Nuclear Medicine (Switzerland).
His clinical and scientific activities are mainly focused on the diagnosis and treatment of thyroid diseases with an emphasis on NUCLEAR IMAGING and therapy, ultrasound-guided interventional procedures and laboratory medicine (THYROID BIOMARKERS).

Bibliographic information

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