© 2018


A Practical Guide for Cancer Immunotherapy

  • Laurence Zitvogel
  • Guido Kroemer

Table of contents

  1. Front Matter
    Pages i-x
  2. Laurence Zitvogel, Guido Kroemer
    Pages 1-2
  3. Fundamentals in I-O

    1. Front Matter
      Pages 3-3
    2. Yann Vano, Nicolas A. Giraldo, Wolf Herman Fridman, Catherine Sautès-Fridman
      Pages 5-21
    3. Weimin Wang, Michael Green, J. Rebecca Liu, Theodore S. Lawrence, Weiping Zou
      Pages 23-39
    4. Martin Rao, Liu Zhenjiang, Qingda Meng, Georges Sinclair, Ernest Dodoo, Markus Maeurer
      Pages 41-67
    5. Thaiz Rivera Vargas, Lionel Apetoh
      Pages 69-95
    6. Anthony R. Cillo, Dario A. A. Vignali
      Pages 97-113
    7. Dipti Vijayan, Mark J. Smyth, Michele W. L. Teng
      Pages 115-141
    8. N. Bendriss-Vermare, N. Gourdin, N. Vey, J. Faget, V. Sisirak, I. Labidi-Galy et al.
      Pages 143-161
    9. Kevin Alicea-Torres, Dmitry I. Gabrilovich
      Pages 181-197
    10. Mélanie Bruchard, Francois Ghiringhelli
      Pages 199-213
    11. Oliver Kepp, Jonathan Pol, Laurence Zitvogel, Guido Kroemer
      Pages 215-229
  4. Breakthrough Status

    1. Front Matter
      Pages 247-247
    2. Cornelis J. M. Melief
      Pages 249-261
    3. Maria Agarwal, Cornelia Trimble
      Pages 263-274
    4. Laura Chiossone, Eric Vivier
      Pages 275-288
    5. George C. Prendergast, William J. Malachowski, Arpita Mondal, Peggy Scherle, Alexander J. Muller
      Pages 289-307

About this book


In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals.

Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.


Cancer Immunotherapy Immuno-Oncology Cancer Vaccines Biomarkers Immunopathology

Editors and affiliations

  • Laurence Zitvogel
    • 1
  • Guido Kroemer
    • 2
  1. 1.Gustave Roussy Cancer Center Villejuif CedexFrance
  2. 2.Gustave Roussy Cancer Center Villejuif CedexFrance

About the editors

Laurence Zitvogel, MD, PhD (Tumor Immunology), PU-PH Faculty Paris Sud, University Paris XI (Clinical Biology), graduated in Medical Oncology from the School of Medicine of the University of Paris in 1992. Dr. Zitvogel started her scientific career at the University of Pittsburgh in Michael Lotze’s laboratory. She subsequently became Research Director at Institut National de la Santé et Recherche Médicale U1015 and is currently Professor of Immunology/Biology at the University of Paris Medical School and Scientific Director of the Immuno-Oncology programme at Institut Gustave Roussy (Villejuif, France), the largest cancer center in Europe. She has made very important contributions to the field of cancer immunology and immunotherapy and has brought together basic and translational research, including the design of cancer therapies, through combined animal studies and phase I/II patient trials. She pioneered the concept of immunogenic cell death and her team discovered the critical role and impact of gut microbiota in cancer immunosurveillance and therapies. She has received many awards, including the INSERM Prize for Translational Research and The Charles Rodolphe Brupbacher Prize for Cancer Research 2017.


Guido Kroemer obtained his MD in 1985 from the University of Innsbruck (Austria) and his PhD in molecular biology in 1992 from the Autonomous University of Madrid (Spain). He is currently a professor at the Faculty of Medicine of the University of Paris Descartes/Paris V, Director of the INSERM Unit “Apoptosis, Cancer and Immunity”, Director of the Metabolomics and Cell Biology platforms of the Gustave Roussy Cancer Campus (Villejuif-Grand Paris), and a practitioner at the Hôpital Européen Georges-Pompidou in Paris. He is also Director of the Paris Alliance of Cancer Research Institutes (PACRI) and the LabEx “Immuno-Oncology”. He is best known for the discoveries that mitochondrial membrane permeabilization constitutes a decisive step in regulated cell death; that autophagy is a cytoprotective mechanism with lifespan-extending effects; and that anticancer therapies are successful only if they stimulate tumor-targeting immune responses. He has received a number of awards, including the Descartes Prize of the European Union, the Dautrebande Prize (Belgian Royal Academy of Medicine), the Léopold Griffuel Prize (French Association for Cancer Research), and The 2017 Charles Rodolphe Brupbacher Prize for Cancer Research.


Bibliographic information

  • Book Title Oncoimmunology
  • Book Subtitle A Practical Guide for Cancer Immunotherapy
  • Editors Laurence Zitvogel
    Guido Kroemer
  • DOI
  • Copyright Information Springer International Publishing AG 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-319-62430-3
  • Softcover ISBN 978-3-319-87310-7
  • eBook ISBN 978-3-319-62431-0
  • Edition Number 1
  • Number of Pages X, 724
  • Number of Illustrations 2 b/w illustrations, 131 illustrations in colour
  • Topics Oncology
    Cancer Research
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Oncology & Hematology


“This is an excellent book on a topic that currently represents a major therapeutic approach in oncology. Written by leading experts, the book is truly an invaluable resource for anyone interested in understanding how immunology and oncology interface.” (Ravi Salgia, Doody's Book Reviews, July, 2018)