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© 2018

Sickle Cell Disease and Hematopoietic Stem Cell Transplantation

  • Emily Riehm Meier
  • Allistair Abraham
  • Ross M. Fasano
Book

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Sickle Cell Disease

    1. Front Matter
      Pages 1-1
    2. Kerry A. Morrone, Jennifer Davila, W. Beau Mitchell, Deepa Manwani
      Pages 41-64
    3. Claire L. Anderson, Deepika S. Darbari
      Pages 65-86
    4. Emily Riehm Meier
      Pages 87-110
  3. Hematopoietic Stem Cell Transplantation

    1. Front Matter
      Pages 161-161
    2. Karen L. Zimowski, Shanmuganathan Chandrakasan
      Pages 163-184
    3. Robert Sheppard Nickel, Naynesh Kamani
      Pages 199-219
    4. Karim T. Sadak, Angela R. Smith, Monica Bhatia
      Pages 235-249
    5. Elizabeth O. Stenger, Allistair Abraham
      Pages 283-302
  4. Back Matter
    Pages 329-334

About this book

Introduction


This book provides a comprehensive, state-of-the art review of hematopoietic stem cell transplantation (HSCT) for sickle cell disease (SCD).  The book reviews new data about risk prediction for severe SCD, outlines the unique challenges of  HSCT for patients with SCD, profiles the supportive care guidelines for patients who are undergoing HSCT, highlights our current understanding of the best transfusion support for SCD patients prior to, during and after HSCT, and provides new perspectives about the ethics of HSCT for pediatric patients with SCD. Published in the last few years, several landmark phase III trials that utilize matched unrelated and haploidentical donors for HSCT in SCD patients are also placed in context with respect to current management. 

Written by experts in the field, Sickle Cell Disease and Hematopoietic Stem Cell Transplantation is a valuable resource for physicians and researchers dealing with and interested in this challenging, yet exciting, curative therapy for sickle cell disease, that will help guide patient management and stimulate investigative efforts.    

 

Keywords

hydroxyurea molecular phenotyping silent cerebral infarcts reduced intensity conditioning transfusional hemochromatosis GVHD prophylaxis

Editors and affiliations

  • Emily Riehm Meier
    • 1
  • Allistair Abraham
    • 2
  • Ross M. Fasano
    • 3
  1. 1.Indiana Hemophilia and Thrombosis CenterIndianapolisUSA
  2. 2.Division of Blood and Marrow TransplantationChildren’s National Medical CenterWashington, DCUSA
  3. 3.Department of Pathology and Laboratory MedicineEmory University School of MedicineAtlantaUSA

About the editors

Emily Riehm Meier, MD, MSHS
Pediatric Hematologist and Director, Sickle Cell Research, Indiana Hemophilia and Thrombosis Center, Indianapolis, IN, USA

Allistair Abraham, MD
Children’s National Medical Center, Division of Blood and Marrow Transplantation, Washington, DC, USA

Ross M. Fasano, MD
Emory University School of Medicine, Department of Pathology & Laboratory Medicine, Atlanta GA, USA

Bibliographic information

  • Book Title Sickle Cell Disease and Hematopoietic Stem Cell Transplantation
  • Editors Emily Riehm Meier
    Allistair Abraham
    Ross M. Fasano
  • DOI https://doi.org/10.1007/978-3-319-62328-3
  • Copyright Information Springer International Publishing AG 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-319-62327-6
  • Softcover ISBN 978-3-319-87292-6
  • eBook ISBN 978-3-319-62328-3
  • Edition Number 1
  • Number of Pages XIII, 334
  • Number of Illustrations 5 b/w illustrations, 16 illustrations in colour
  • Topics Hematology
  • Buy this book on publisher's site
Industry Sectors
Biotechnology
Health & Hospitals
Oncology & Hematology
Pharma

Reviews

“An authoritative work on hematopoietic stem cell transplantation (HSCT) … . Written by leading expert clinicians and researchers … . this is a very valuable resource for clinicians and scientists dealing with this devastating disease and pursuing a curative therapy.” (Ravi Salgia, Doody's Book Reviews, August, 2018)