© 2017

Personalised Medicine

Lessons from Neurodegeneration to Cancer

  • Sherif El-Khamisy


  • Includes tips on how to apply genome differences in personalized medicine

  • Provides a road map for studying cancer and degenerative disease: two sides of the same coin

  • Each chapter includes 10 takeaway messages to help the reader to learn quickly


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1007)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Anastasios Liakos, Matthieu D. Lavigne, Maria Fousteri
    Pages 17-39
  3. Walaa R. Allam, Mohamed E. Ashour, Amr A. Waly, Sherif El-Khamisy
    Pages 41-58
  4. Rana Alaaeddine, Mira Fayad, Eliana Nehme, Hisham F. Bahmad, Firas Kobeissy
    Pages 59-70
  5. Ahmed Maher, Mohamed F. Abdel Rahman, Mohamed Z. Gad
    Pages 71-88
  6. Guillaume M. Hautbergue
    Pages 89-109
  7. Chloe F. Allen, Pamela J. Shaw, Laura Ferraiuolo
    Pages 111-128
  8. Laila A. Selim, Heba Hassaan
    Pages 129-155
  9. Arwa A. Abugable, Dahlia A. Awwad, Dalia Fleifel, Mohamed M. Ali, Sherif El-Khamisy, Menattallah Elserafy
    Pages 157-178
  10. Sarah Baxendale, Freek van Eeden, Robert Wilkinson
    Pages 179-197
  11. Nicholas F. Blair, Thomas J. R. Frith, Ivana Barbaric
    Pages 225-239
  12. Jayanth S. Chandran, Joseph M. Scarrott, Pamela J. Shaw, Mimoun Azzouz
    Pages 241-257
  13. Back Matter
    Pages 259-260

About this book


The mammalian genome is constantly challenged by exogenous and endogenous threats. Although much is known about the mechanisms that maintain genome integrity, little is known about the applications of this knowledge to combat human disease. The past 20 years has witnessed extensive research and progress in this area and scientists started to design new therapies harnessing individual genetic differences among patients to combat degenerative disorders and cancer. We summarize these advancements and discuss perspectives for the future of personalized medicine.


Cancer DNA repair Degenerative disorders Genome instability Personalised Medicine

Editors and affiliations

  • Sherif El-Khamisy
    • 1
  1. 1.Krebs Institute and Sheffield Institute for Nucleic Acids, Department of Molecular Biology and Biotechnology, Firth CourtUniversity of SheffieldSheffieldUnited Kingdom

Bibliographic information

  • Book Title Personalised Medicine
  • Book Subtitle Lessons from Neurodegeneration to Cancer
  • Editors Sherif El-Khamisy
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI
  • Copyright Information American Association of Pharmaceutical Scientists 2017
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-60731-3
  • Softcover ISBN 978-3-319-86922-3
  • eBook ISBN 978-3-319-60733-7
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages VIII, 260
  • Number of Illustrations 46 b/w illustrations, 52 illustrations in colour
  • Topics Cancer Research
    Gene Function
    Molecular Medicine
  • Buy this book on publisher's site
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