© 2018

The Bethesda System for Reporting Thyroid Cytopathology

Definitions, Criteria, and Explanatory Notes

  • Syed Z. Ali
  • Edmund S. Cibas

Table of contents

  1. Front Matter
    Pages i-xv
  2. Zubair W. Baloch, David S. Cooper, Hossein Gharib, Erik K. Alexander
    Pages 1-6
  3. Barbara A. Crothers, Michael R. Henry, Pinar Firat, Mary C. Frates, Esther Diana Rossi
    Pages 7-18
  4. Tarik M. Elsheikh, Béatrix Cochand-Priollet, Soon Won Hong, Mary K. Sidawy
    Pages 19-48
  5. Jeffrey F. Krane, Ritu Nayar, Andrew A. Renshaw
    Pages 49-70
  6. Michael R. Henry, William H. Westra, Jeffrey F. Krane, Fernando Schmitt
    Pages 71-80
  7. William C. Faquin, Claire W. Michael, Andrew A. Renshaw, Philippe Vielh
    Pages 81-100
  8. Paul A. VanderLaan, Ashish Chandra, Armando C. Filie, Gregory W. Randolph, Celeste N. Powers
    Pages 101-118
  9. Marc P. Pusztaszeri, Manon Auger, Edward B. Stelow, Grace C. H. Yang, Miguel A. Sanchez, Virginia A. LiVolsi
    Pages 119-156
  10. Michiya Nishino, Marc P. Pusztaszeri, Martha B. Pitman
    Pages 157-175
  11. Massimo Bongiovanni, Guido Fadda, William C. Faquin
    Pages 177-188
  12. Gregg A. Staerkel, Justin A. Bishop, Vinod B. Shidham, Matthew A. Zarka
    Pages 189-204
  13. Lester J. Layfield, Kennichi Kakudo
    Pages 205-230
  14. Back Matter
    Pages 231-236

About this book


  The first edition of The Bethesda System for Reporting Thyroid Cytopathology was published in 2010 and has greatly influenced the practice of thyroid cytopathology. The terminology proposed and illustrated in this text has been widely adopted not only in the U.S. but also abroad. It has become an essential text for pathology trainees and practicing pathologists examining thyroid fine needle aspiration (FNA) specimens.

  Since 2010, there have been a number of important advances in the management of patients with nodular thyroid disease and in the understanding of the biology of thyroid cancer. This new edition includes these advances that impact terminology for reporting thyroid cytopathology. In particular, it incorporates a discussion of the recently implemented and now widespread use of molecular testing of thyroid FNA samples, which has transformed the management of patients with nodular thyroid disease in the U.S.. In addition, this edition accommodates the recent changes to the classification of thyroid cancer, most notably the introduction of a new thyroid diagnosis, that of "non-invasive follicular tumor with papillary-like nuclear features (NIFTP)".

  Thoroughly revised and updated, The Bethesda System for Reporting Thyroid Cytopathology, Second Edition will provide the reader with a unified approach to diagnosing and reporting thyroid FNA interpretations. It serves as a reference guide not just for pathologists, but also endocrinologists, surgeons, and radiologists.


cancer cell cytology cytopathology lymphoma Follicular Neoplasm Medullary Thyroid Carcinoma Metastatic Tumors

Editors and affiliations

  • Syed Z. Ali
    • 1
  • Edmund S. Cibas
    • 2
  1. 1.Department of PathologyThe Johns Hopkins Hospital/The Johns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Department of PathologyBrigham and Women’s Hospital and Harvard Medical SchoolBostonUSA

About the editors

Syed Z. Ali, MD

Professor of Pathology

The Johns Hopkins Hospital

Baltimore, MD


Edmund S. Cibas, MD

Professor of Pathology

Harvard Medical School

Brigham and Women's Hospital

Boston, MA


Bibliographic information

  • Book Title The Bethesda System for Reporting Thyroid Cytopathology
  • Book Subtitle Definitions, Criteria, and Explanatory Notes
  • Editors Syed Z. Ali
    Edmund S. Cibas
  • DOI
  • Copyright Information Springer International Publishing AG 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Softcover ISBN 978-3-319-60569-2
  • eBook ISBN 978-3-319-60570-8
  • Edition Number 2
  • Number of Pages XV, 236
  • Number of Illustrations 0 b/w illustrations, 224 illustrations in colour
  • Topics Pathology
    Surgical Oncology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals


“This is the second edition of the most widely accepted standard for reporting thyroid cytopathology. … This book is aimed at pathologists, pathology trainees, and cytopathology technologists. The book also provides useful information for endocrinologists, surgeons, and radiologists. … This is a valuable resource for pathologists and provides important updates to the original edition. It maintains and updates the original classification scheme while also providing an excellent atlas, explanatory notes, and clinical utility.” (Brian S. Soles, Doody's Book Reviews, February, 2018)