About this book
This highly interdisciplinary thesis reports ontwo innovative photonic biosensors that combine multiple simultaneous measurements to provide unique insights into the activity and structure of surface immobilized biological molecules. In addition, it presents a new silicon photonic biosensor that exploits two cascaded resonant sensors to provide two independent measurements of a biological layer immobilized on the surface. By combining these two measurements, it is possible to unambiguously quantify the density and thickness of the molecular layer; here, the approach’s ability to study molecular conformation and conformational changes in real timeis demonstrated.
The electrophotonic biosensor integrates silicon photonics with electrochemistry into a single technology. This multi-modal biosensor provides a number of unique capabilities that extend the functionality of conventional silicon photonics. For example, by combining the complementary information revealed by simultaneous electrochemical and photonic measurements, it is possible to provide unique insights into on-surface electrochemical processes. Furthermore, the ability to create electrochemical reactions directly on the silicon surface provides a novel approach for engineering the chemical functionality of the photonic sensors. The electrophotonic biosensor thus represents a critical advance towards the development of very high-density photonic sensor arrays for multiplexed diagnostics.
Electro-photonic Biosensor Photonic Biosensing Ring Resonators Biosensors Silicon Biosensing Multiplexed DNA Detection Quantifying Biomolecular Layers
- DOI https://doi.org/10.1007/978-3-319-60501-2
- Copyright Information Springer International Publishing AG 2017
- Publisher Name Springer, Cham
- eBook Packages Physics and Astronomy Physics and Astronomy (R0)
- Print ISBN 978-3-319-60500-5
- Online ISBN 978-3-319-60501-2
- Series Print ISSN 2190-5053
- Series Online ISSN 2190-5061
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