© 2017

Mechanisms of Vascular Defects in Diabetes Mellitus

  • C.C. Kartha
  • Surya Ramachandran
  • Radhakrishna M. Pillai
  • Gives a unique approach to describing vascular disease progression in diabetes

  • Presents our latest understanding of the pathogenesis and pathophysiology of vascular diseases in diabetes mellitus described by a panel of renowned experts in the field of vascular biology and diabetology

  • Is a ‘must read’ of significant value and interest to clinicians, researchers, postdoctoral researchers and medical and non-medical graduate students.


Part of the Advances in Biochemistry in Health and Disease book series (ABHD, volume 17)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Viswanathan Mohan, Rajendra Pradeepa
      Pages 3-23
  3. Pathogenesis

    1. Front Matter
      Pages 25-25
    2. Dwaipayan Bharadwaj, Anjali Singh
      Pages 27-71
    3. Srikanth Vallurupalli, Jawahar L. Mehta
      Pages 73-93
    4. Vikrant Rai, Devendra K. Agrawal
      Pages 95-107
    5. Shivam Chandel, Rakesh Kumar Tiwari, Madhulika Dixit
      Pages 109-128
    6. Uma Nahar Saikia, Suvradeep Mitra
      Pages 129-139
    7. Surya Ramachandran, Radhakrishna M. Pillai, C. C. Kartha
      Pages 141-158
    8. Nicoleta Alexandru, Irina Titorencu, Sabina Frunzã, Emma Weiss, Elisabeta Bãdilã, Adriana Georgescu
      Pages 159-208
    9. Anita Mahadevan, Shankar S. Krishna
      Pages 249-272
  4. Molecular Mechanisms

    1. Front Matter
      Pages 273-273
    2. Ana Cristina Simões e Silva, Rodrigo Novaes Ferreira, Aline Silva Miranda
      Pages 275-291
    3. Camille M. Balarini
      Pages 293-303
    4. Madhu B. Anand-Srivastava
      Pages 305-324
  5. Hemostatic Factors

    1. Front Matter
      Pages 359-359

About this book


This book comprising 24 chapters is devoted to the mechanisms for the pathogenesis of the spectrum of vascular diseases in diabetes. Cellular events and molecular pathways that regulate the structure and function of both small and large arteries, the dysregulation in these vessels caused by hyperglycemia, oxidative stress, metabolic and haemostatic derangements secondary to diabetes, are discussed. Mechanisms of vascular remodelling and rupture of atherosclerotic plaques in diabetes are also covered.  Several of the reviews also discuss therapeutic targets and drugs employed to reduce endothelial dysfunction and vascular inflammation in diabetes. All articles are authored by experts in their respective research fields.

This compendium will be of interest to both basic scientists and clinicians in the pursuit of unravelling the molecular basis of vascular diseases and also to those who seek to identify targets for therapy of vascular complications of diabetes.


Diabetes Mellitus Pathophysiology of vascular disease Diabetic vasculopathy Hyperglycaemia Endothelial dysfunction Oxidative stress diabetes

Editors and affiliations

  • C.C. Kartha
    • 1
  • Surya Ramachandran
    • 2
  • Radhakrishna M. Pillai
    • 3
  1. 1.Division of Cardiovascular Diseases and Diabetes BiologyRajiv Gandhi Centre for BiotechnologyThiruvananthapuramIndia
  2. 2.Division of Cardiovascular Diseases and Diabetes BiologyRajiv Gandhi Centre for BiotechnologyThiruvananthapuramIndia
  3. 3.Translational Cancer Research ProgramRajiv Gandhi Centre for BiotechnologyThiruvananthapuramIndia

About the editors

Dr.  Chandrasekharan C.  Kartha is an Honorary Distinguished Professor in the Division of Cardiovascular Diseases and Diabetes Biology at Rajiv Gandhi Center for Biotechnology at Thiruvananthapuram, India. He is a pathologist by training and has made significant contributions to the understanding of the cellular and molecular mechanisms of vascular diseases and endomyocardial fibrosis, a tropical cardiomyopathy. He is an elected fellow of Royal College of Physicians (London), International Academy of Cardiovascular Sciences, National Academy of Medical Sciences (India) National Academy of Sciences (India) and Indian Academy of sciences. He has served on the editorial boards of several journals and in grant review committees of several India government agencies funding medical research and science and technology activities. He has organized several national and international conferences on cardiovascular themes and has been an invited speaker at several national and international meetings. He has published more than 120 papers in refereed journals, 15 chapters in books and edited 5 books. He is the current President of Academy of Cardiovascular Sciences, the India section of International Academy of Cardiovascular Sciences.

Bibliographic information

  • Book Title Mechanisms of Vascular Defects in Diabetes Mellitus
  • Editors C.C. Kartha
    Surya Ramachandran
    Radhakrishna M. Pillai
  • Series Title Advances in Biochemistry in Health and Disease
  • Series Abbreviated Title Biochemistry
  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-60323-0
  • Softcover ISBN 978-3-319-86836-3
  • eBook ISBN 978-3-319-60324-7
  • Edition Number 1
  • Number of Pages XVIII, 579
  • Number of Illustrations 21 b/w illustrations, 54 illustrations in colour
  • Topics Cell Biology
  • Buy this book on publisher's site
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