Mechanisms of Vascular Defects in Diabetes Mellitus

  • C.C. Kartha
  • Surya Ramachandran
  • Radhakrishna M. Pillai

Part of the Advances in Biochemistry in Health and Disease book series (ABHD, volume 17)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Viswanathan Mohan, Rajendra Pradeepa
      Pages 3-23
  3. Pathogenesis

    1. Front Matter
      Pages 25-25
    2. Dwaipayan Bharadwaj, Anjali Singh
      Pages 27-71
    3. Srikanth Vallurupalli, Jawahar L. Mehta
      Pages 73-93
    4. Vikrant Rai, Devendra K. Agrawal
      Pages 95-107
    5. Shivam Chandel, Rakesh Kumar Tiwari, Madhulika Dixit
      Pages 109-128
    6. Uma Nahar Saikia, Suvradeep Mitra
      Pages 129-139
    7. Surya Ramachandran, Radhakrishna M. Pillai, C. C. Kartha
      Pages 141-158
    8. Nicoleta Alexandru, Irina Titorencu, Sabina Frunzã, Emma Weiss, Elisabeta Bãdilã, Adriana Georgescu
      Pages 159-208
    9. Anita Mahadevan, Shankar S. Krishna
      Pages 249-272
  4. Molecular Mechanisms

    1. Front Matter
      Pages 273-273
    2. Ana Cristina Simões e Silva, Rodrigo Novaes Ferreira, Aline Silva Miranda
      Pages 275-291
    3. Camille M. Balarini
      Pages 293-303
    4. Madhu B. Anand-Srivastava
      Pages 305-324
  5. Hemostatic Factors

    1. Front Matter
      Pages 359-359
    2. Kanjaksha Ghosh
      Pages 361-376
    3. Gundu H. R. Rao
      Pages 395-419
  6. Metabolic Factors

    1. Front Matter
      Pages 421-421
    2. Shweta Bhat, Sheon Mary, Ashok P. Giri, Mahesh J. Kulkarni
      Pages 423-449
    3. Arungovind G, Kamalanathan A. S, Krishnan Venkataraman
      Pages 451-467
    4. Pankaj Chaturvedi
      Pages 469-479
  7. Pharmacological Therapies

    1. Front Matter
      Pages 481-481
    2. Rajagopal Desikan, Chandrakala Aluganti Narasimhulu, Bobby Khan, Sanjay Rajagopalan, Sampath Parthasarathy
      Pages 535-571
  8. Back Matter
    Pages 573-579

About this book


This book comprising 24 chapters is devoted to the mechanisms for the pathogenesis of the spectrum of vascular diseases in diabetes. Cellular events and molecular pathways that regulate the structure and function of both small and large arteries, the dysregulation in these vessels caused by hyperglycemia, oxidative stress, metabolic and haemostatic derangements secondary to diabetes, are discussed. Mechanisms of vascular remodelling and rupture of atherosclerotic plaques in diabetes are also covered.  Several of the reviews also discuss therapeutic targets and drugs employed to reduce endothelial dysfunction and vascular inflammation in diabetes. All articles are authored by experts in their respective research fields.

This compendium will be of interest to both basic scientists and clinicians in the pursuit of unravelling the molecular basis of vascular diseases and also to those who seek to identify targets for therapy of vascular complications of diabetes.


Diabetes Mellitus Pathophysiology of vascular disease Diabetic vasculopathy Hyperglycaemia Endothelial dysfunction Oxidative stress

Editors and affiliations

  • C.C. Kartha
    • 1
  • Surya Ramachandran
    • 2
  • Radhakrishna M. Pillai
    • 3
  1. 1.Division of Cardiovascular Diseases and Diabetes BiologyRajiv Gandhi Centre for BiotechnologyThiruvananthapuramIndia
  2. 2.Division of Cardiovascular Diseases and Diabetes BiologyRajiv Gandhi Centre for BiotechnologyThiruvananthapuramIndia
  3. 3.Translational Cancer Research ProgramRajiv Gandhi Centre for BiotechnologyThiruvananthapuramIndia

Bibliographic information

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