© 2017

G-Protein-Coupled Receptor Dimers

  • Katharine Herrick-Davis
  • Graeme Milligan
  • Giuseppe Di Giovanni

Part of the The Receptors book series (REC, volume 33)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Richard J. Ward, Sara Marsango, John D. Pediani, Graeme Milligan
      Pages 15-38
    3. Valerica Raicu, William F. Schmidt
      Pages 39-75
  3. Receptors

    1. Front Matter
      Pages 77-77
    2. Wesley B. Asher, Signe Mathiasen, Michael D. Holsey, Steven G. Grinnell, Nevin A. Lambert, Jonathan A. Javitch
      Pages 99-127
    3. Ellinor Grinde, Katharine Herrick-Davis
      Pages 129-172
    4. Salvador Sierra, Ivone Gomes, Lakshmi A. Devi
      Pages 173-206
    5. Aylin C. Hanyaloglu, F. Fanelli, K. C. Jonas
      Pages 207-231
    6. Kaleeckal G. Harikumar, Laurence J. Miller
      Pages 273-287
    7. Joseph J. Gingell, Christopher S. Walker, Debbie L. Hay
      Pages 289-305
    8. Qing R. Fan, William Y. Guo, Yong Geng, Marisa G. Evelyn
      Pages 307-325
    9. Veronika Hlaváčková, Laurent Prézeau, Jean-Philippe Pin, Jaroslav Blahos
      Pages 327-356
  4. Assembly and Trafficking

About this book


G-protein-coupled receptors (GPCRs) are believed to be the largest family of membrane proteins involved in signal transduction and cellular responses. They dimerize (form a pair of macromolecules) with a wide variety of other receptors. The proposed book will provide a comprehensive overview of GPCR dimers, starting with a historical perspective and including, basic information about the different dimers, how they synthesize, their signaling properties, and the many diverse physiological processes in which they are involved.  In addition to presenting information about healthy GPCR dimer activity, the book will also include a section on their pathology and therapeutic potentials.


Dimers GPRC Signaling Synthesis Therapeutic Potential

Editors and affiliations

  • Katharine Herrick-Davis
    • 1
  • Graeme Milligan
    • 2
  • Giuseppe Di Giovanni
    • 3
  1. 1.Department of Neuroscience and Experimental TherapeuticsAlbany Medical CollegeAlbanyUSA
  2. 2.Centre for Translational Pharmacology, Institute of Molecular Cell and Systems Biology, College of Medical, Veterinary and Life SciencesUniversity of GlasgowGlasgow, ScotlandUnited Kingdom
  3. 3.Department of Physiology and BiochemistryUniversity of MaltaMsidaMalta

About the editors

Katharine Herrick-Davis is Professor of Neuroscience and Experimental Therapeutics at Albany Medical College, Albany, USA. Her research has focused on investigating receptor dimerization and how it affects receptor function using the 5-HT2C receptor as a model system. 

Graeme Milligan is Professor of Molecular Pharmacology, University of Glasgow, U.K. he is the Dean of Research, College of Medical, Veterinary and Life Sciences, University of Glasgow. His main research group centres on the function, structure and regulation of GPCRs and their interacting proteins. 

Giuseppe Di Giovanni is Professor of Human Physiology, University of Malta, Malta. He is the President of the Malta Neuroscience Network and Treasurer of the Mediterranean Neuroscience Society. His research has focused on the pathophysiology of the monoaminergic systems in different neuropsychiatric disorders, such as Parkinson's disease, depression, drug of abuse and epilepsy.

Bibliographic information

  • Book Title G-Protein-Coupled Receptor Dimers
  • Editors Katharine Herrick-Davis
    Graeme Milligan
    Giuseppe Di Giovanni
  • Series Title The Receptors
  • Series Abbreviated Title The Receptors
  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Humana Press, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-60172-4
  • Softcover ISBN 978-3-319-86795-3
  • eBook ISBN 978-3-319-60174-8
  • Series ISSN 1048-6909
  • Series E-ISSN 2524-6488
  • Edition Number 1
  • Number of Pages XVII, 501
  • Number of Illustrations 12 b/w illustrations, 58 illustrations in colour
  • Topics Neurosciences
  • Buy this book on publisher's site
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