Biomarkers for Endometriosis

State of the Art

  • Thomas D'Hooghe

Table of contents

  1. Front Matter
    Pages i-xii
  2. Nicholas Galazis
    Pages 27-39
  3. Aristeidis H. Katsanos, Kalliroi Kyriakidi, Fotini B. Karassa, Dimitrios Politis, Alexandros Skamnelos, Dimitrios K. Christodoulou et al.
    Pages 41-75
  4. Silke Apers, Eline A. F. Dancet, Thomas D’Hooghe
    Pages 77-82
  5. Sang Hong Lee, Yadav Sapkota, Jenny Fung, Grant W. Montgomery
    Pages 83-93
  6. Leslie V. Farland, Divya K. Shah, Marina Kvaskoff, Krina T. Zondervan, Stacey A. Missmer
    Pages 95-121
  7. Amelie Fassbender, Dorien O, Christian M. Becker, Thomas D’Hooghe
    Pages 123-139
  8. Ndeye-Aicha Gueye, Jamie Stanhiser, Lindsey Valentine, Alexander Kotlyar, Linnea Goodman, Tommaso Falcone
    Pages 141-163
  9. Lusine Aghajanova, R. O. Burney, N. D. Tran, Linda C. Giudice
    Pages 165-183
  10. Amelie Fassbender, Antoine Hubert, Etienne Waelkens, Dorien O, Thomas D’Hooghe
    Pages 185-198
  11. Nilufer Rahmioglu, Amelie Fassbender, Allison Vitonis, Lone Hummelshoj, David Adamson, Christian M. Becker et al.
    Pages 199-226
  12. Merli Saare, Maire Peters, Alar Aints, Triin Laisk-Podar, Andres Salumets, Signe Altmäe
    Pages 227-258
  13. Back Matter
    Pages 259-267

About this book


This book presents an overview of the diagnostic performance of non- or semi-invasive tests for endometriosis in peripheral blood, endometrium, saliva, peritoneal fluid and urine. The value of existing and emerging systems biology technologies for biomarker development is addressed in several chapters on genetics, microarrays, proteomics and metabolomics. Although tests with high sensitivity and acceptable specificity have been developed, sometimes validated in independent populations and seem promising, more research is needed to translate these data into clinical benefit for patients and coordinate efforts internationally to standarize analysis, reports and operating procedures. The gold standard to diagnose endometriosis is currently through laparoscopic inspection with histological confirmation, a surgical procedure with rare but significant potential risks for the patients. A non-invasive test for endometriosis would be critical for the early detection of endometriosis of symptomatic women with pelvic pain and/or subfertility with normal ultrasound. This would include nearly all cases of minimal-mild endometriosis, some cases of moderate-severe endometriosis without a clearly visible ovarian endometrioma and cases with pelvic adhesions and/or other pelvic pathology, who might benefit from surgery to improve pelvic pain and/or subfertility. Such a test would also be useful in symptomatic women with ultrasound imaging suspicious for endometriosis, since it may be difficult to differentiate an ovarian endometrioma from other ovarian cysts and since the quality of ultrasound imaging is highly variable worldwide.


Biomarker development Endometrial biomarkers Endometriosis Proteomic biomarkers Genetic biomarkers Metabolomics

Editors and affiliations

  • Thomas D'Hooghe
    • 1
  1. 1.Department of Development and Regeneration Organ Systems, Group Biomedical SciencesKU Leuven (University of Leuven)LeuvenBelgium

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-59854-3
  • Online ISBN 978-3-319-59856-7
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals