Phosphodiesterases: CNS Functions and Diseases

  • Han-Ting Zhang
  • Ying Xu
  • James M. O'Donnell

Part of the Advances in Neurobiology book series (NEUROBIOL, volume 17)

Table of contents

  1. Front Matter
    Pages i-xix
  2. PDEs and Signaling, Circuitry, and Implications of CNS Functions and Disorders

  3. PDEs in Cognition of Aging and Alzheimer’s Disease

  4. PDEs in Parkinson’s and Huntington’s Diseases

  5. PDEs and Psychiatric Disorders

    1. Front Matter
      Pages 305-305
    2. Chong Zhang, Lindsay M. Lueptow, Han-Ting Zhang, James M. O’Donnell, Ying Xu
      Pages 307-347
    3. Lawrence P. Wennogle, Helen Hoxie, Youyi Peng, Joseph P. Hendrick
      Pages 349-384
    4. Gretchen L. Snyder, Kimberly E. Vanover
      Pages 385-409
  6. PDEs and Others

    1. Front Matter
      Pages 411-411
    2. Rui-Ting Wen, Jian-Hui Liang, Han-Ting Zhang
      Pages 413-444

About this book


PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic neucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthiritis.  This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases.  The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.


Central Nervous System Cyclic Nucleotides Neurodegenerative Disease Neuropsychiatric Disorders Phosphodiesterases

Editors and affiliations

  • Han-Ting Zhang
    • 1
  • Ying Xu
    • 2
  • James M. O'Donnell
    • 3
  1. 1.Department of Behavioral Medicine and Psychiatry; Department of Physiology and Pharmacology; Institute of PharmacologyWest Virginia University Health Sciences Center; Taishan Medical UniversityMorgantown; Taian, ChinaUSA
  2. 2.School of Pharmacy and Pharmaceutical SciencesUniversity at Buffalo The State University of New YorkBuffaloUSA
  3. 3.School of Pharmacy and Pharmaceutical SciencesUniversity at Buffalo The State University of New YorkBuffaloUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-58809-4
  • Online ISBN 978-3-319-58811-7
  • Series Print ISSN 2190-5215
  • Series Online ISSN 2190-5223
  • Buy this book on publisher's site
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