© 2018

Metal Allergy

From Dermatitis to Implant and Device Failure

  • Jennifer K Chen
  • Jacob P. Thyssen

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Metal: Overview

    1. Front Matter
      Pages 1-1
    2. C. Peter Cutler
      Pages 3-16
    3. Morten Stendahl Jellesen
      Pages 17-22
    4. Ines Anderie, Kerstin Schulte
      Pages 31-38
  3. Metals, Skin, and the Immune System

    1. Front Matter
      Pages 55-55
    2. Francesca Larese Filon
      Pages 67-74
    3. Marc Schmidt, Matthias Goebeler
      Pages 75-84
    4. Trine Hilkjær Petersen, Carsten Geisler, Charlotte Menné Bonefeld
      Pages 85-95
    5. Angela Rizzi, Eleonora Nucera, Domenico Schiavino
      Pages 97-105
    6. Radoslaw Spiewak
      Pages 107-124
    7. Thomas Rustemeyer
      Pages 125-133
  4. Common Sources of Metal Exposure

    1. Front Matter
      Pages 135-135
    2. Carsten R. Hamann, Dathan Hamann
      Pages 137-162
    3. Vera Mahler
      Pages 163-175
    4. Malgorzata M. Brzóska, Malgorzata Galażyn-Sidorczuk, Sylwia Borowska
      Pages 177-196
    5. Kelsey E. Hirotsu, Jennifer K. Chen
      Pages 197-209

About this book


This volume has been compiled in response to the ongoing revolution in our understanding of metal contact allergy, and the ensuing challenge this has created for clinicians and others to synthesize large amounts of sometimes contradictory data. It opens by providing a comprehensive overview of the use and regulation of metals in our society, metal properties, and available testing methodologies. Common and uncommon metal allergens and sources of exposure are then reviewed in depth, and detailed sections are devoted to hypersensitivity to metal implants (which may be associated with device failure and/or dermatitis), metal allergy in select patient populations, and less frequently encountered manifestations of metal allergy.

The prevalence of metal allergy in the general population is high: up to 17% of people are allergic to nickel, and 1–3% to cobalt and chromium. Environmental sources of metal exposure include jewelry, clothing, electronic devices, coins, leather, diet, and occupational exposure. As metals are ubiquitous, this book will be an indispensable reference text for a wide range of clinicians and investigators, meeting the needs of all who are interested in metal allergy and its diagnosis and management.




Metallic Implants Allergic contact dermatitis Nickel Contact allergy Patch testing Metal exposure Metal allergy

Editors and affiliations

  • Jennifer K Chen
    • 1
  • Jacob P. Thyssen
    • 2
  1. 1.Department of Dermatology, Stanford University School of MedicineRedwood CityUSA
  2. 2.Department of Dermatology and Allergy Herlev and Gentofte Hospital University of CopenhagenHellerupDenmark

About the editors

Jennifer Chen is currently an assistant professor at Stanford University School of Medicine. She holds an MD from Johns Hopkins University and has completed a Howard Hughes Medical Institute fellowship at Stanford University School of Medicine. Dr. Chen has published 25 articles and authored 4 book chapters. Her areas of interest include allergic contact dermatitis and medical dermatology. She regularly delivers presentations at international meetings and has served as a consultant for the Women's Health and Contemporary Pediatrics magazines, GreatistReader's Digest, and the local news. 

Jacob Thyssen has worked in clinical dermatology for more than 10 years and holds PhD and DmSci degrees from the University of Copenhagen in Denmark, where he is currently an associate professor. He has authored 250 articles, 12 book chapters and 2 textbooks (on patch testing and filaggrin proteins). Dr. Thyssen has received international awards for his research, including the LEO Pharma Research Foundation for best investigator aged below 45 years in the Nordic countries. His research has focused on atopic and contact dermatitis, allergies, and the skin barrier. He has been a research fellow in the USA, visiting Harvard Medical School and UCSF. Dr. Thyssen is a regular speaker at international meetings. He enjoys treating patients with dermatitis and metal allergies on a daily basis in the Gentofte Clinic in Copenhagen, Denmark.



Bibliographic information

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“Metal Allergy is a tempting read for arthroplasty surgeons, especially metal-on-metal enthusiasts and those struggling with trunnionosis. The hardcover book is presented to the usual high Springer standard. Chapter authors are mostly from the USA and continental Europe. … This book will mainly be of interest to orthopaedic surgeons dealing with metal bearings.” (J. Brockwell, The Bone & Joint Journal, Vol. 100-B (11), November, 2018)