© 2017

Protein Deimination in Human Health and Disease

  • Anthony P. Nicholas
  • Sanjoy K. Bhattacharya
  • Paul R. Thompson

Table of contents

  1. Front Matter
    Pages i-ix
  2. Masaki Unno, Kenji Kizawa, Hidenari Takahara
    Pages 33-46
  3. Chinatsu Mukai, Brooke A. Marks, Scott A. Coonrod
    Pages 47-61
  4. Dres Damgaard, Ger J. M. Pruijn
    Pages 63-83
  5. Bence Rethi, Akilan Krishnamurthy, Anca I. Catrina
    Pages 85-97
  6. Katarzyna Gawron, Anna Montgomery, Katarzyna Łazarz-Bartyzel, Grzegorz Bereta, Maria Chomyszyn-Gajewska, Patrick Venables et al.
    Pages 99-135
  7. Nishant Dwivedi, Hui-Hsin Chang, I-Cheng Ho
    Pages 137-159
  8. Guido Valesini, Tania Colasanti, Cristiano Alessandri, Michele Bombardieri, Fabrizio Conti, Maurizio Sorice
    Pages 161-172
  9. J. Fert-Bober, E. L. Crowgey, J. Sokolove, J. T. Giles, J. M. Bathon, J. E. Van Eyk
    Pages 205-225
  10. Sigrun Lange, Selina Wray, Mike Devine, Mar Matarin, John Hardy
    Pages 227-239
  11. Di Ding, Mabel Enriquez-Algeciras, Sanjoy K. Bhattacharya, Vera L. Bonilha
    Pages 241-251
  12. Mabel Enriquez-Algeciras, Di Ding, Dana P. Ascherman, Sanjoy K. Bhattacharya
    Pages 253-273
  13. Rachel C. Lazarus, John E. Buonora, Alaa Kamnaksh, Michael N. Flora, James G. Freedy, Gay R. Holstein et al.
    Pages 275-291
  14. Yoshitaka Kondo, Eun-Kyoung Choi, Yong-Sun Kim, Akihito Ishigami
    Pages 293-315
  15. William R. Meador, John R. Rinker, Anthony P. Nicholas
    Pages 317-336

About this book


Published in 2014,  Protein Deimination in Human Health and Disease  was the first book on this novel post-translational modification, in which selected positively-charged arginine amino acids are converted to neutral citrulline amino acids by the peptidyl-arginine deiminase (PAD) family of enzymes. This area of research continues to expand rapidly, necessitating the need for this second edition. Chronicling the latest inflammatory, epigenetic, neurodegenerative, and carcinogenic processes,  Protein Deimination in Human Health and Disease, Second Edition, updates the latest advances in deimination research, including new information on PAD enzyme structure and activity, and how PAD knock-out animals are being used to study known and newly-discovered links to various human diseases.

The first edition outlined what was known about citrullinated proteins in normal tissues such as skin and hair, as well as in maladies such as rheumatoid arthritis (RA), multiple sclerosis (MS), Alzheimer’s disease (AD), glaucoma, peripheral nerve injury, neonatal hypoxic brain damage, and breast cancer. This second edition addresses numerous additional disorders such as diabetes, asthma, traumatic brain injury, inflammatory bowel disease, lupus, bone disease, heart failure, fronto-temporal dementia, and prostate and colon cancer. It also provides updates on the deimination research covering the three seminal diseases first linked to this process (RA, MS and AD), and details how auto-antibodies against citrullinated proteins contribute to disease. In addition, new hypotheses on the possible pathologic mechanisms of citrullinated myelin basic protein and glial fibrillary acidic protein are also proposed. This second edition also outlines the latest developments in therapeutic strategies, including the use of new PAD antagonists and innovative techniques such as micro-vescicles and stem cells as possible mechanisms to treat these conditions.


aging auto-immune disease cancer epigenetics neurodegenerative disease peripheral nerve injury post-translational modification rheumatoid arthritis

Editors and affiliations

  • Anthony P. Nicholas
    • 1
  • Sanjoy K. Bhattacharya
    • 2
  • Paul R. Thompson
    • 3
  1. 1.Department of NeurologyUniversity of Alabama at Birmingham and The Birmingham Veterans Administration Medical CenterBirminghamUSA
  2. 2.Bascom Palmer Eye InstituteUniversity of MiamiMiamiUSA
  3. 3.Department of Biochemistry and Molecular PharmacologyUMASS Medical SchoolWorcesterUSA

About the editors

Anthony Nicholas, University of Alabama - Birmingham
Sanjoy Bhattacharya, University of Miami
Paul R. Thompson, University of Massachusetts Medical School 

Bibliographic information

Industry Sectors
Health & Hospitals