© 2017

Molecules, Systems and Signaling in Liver Injury

  • Wen-Xing Ding
  • Xiao-Ming Yin

Part of the Cell Death in Biology and Diseases book series (CELLDEATH)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Edward N. Harris, Justin L. Mott
    Pages 1-21
  3. April O’Brien, Chad Hall, Laurent Ehrlich, Tianhao Zhou, Fanyin Meng, Gianfranco Alpini et al.
    Pages 23-38
  4. Fatemeh P. Parvin-Nejad, Scott L. Friedman
    Pages 39-52
  5. Hayato Hikita, Tetsuo Takehara
    Pages 75-85
  6. Kari Nichole Nejak-Bowen, Satdarshan Pal Singh Monga
    Pages 87-132
  7. Rui Kang, Daolin Tang
    Pages 133-158
  8. Carl W. Decker, Joseph G. Casian, Kim Tho Nguyen, Luke A. Horton, Madhuri P. Rao, Kai H. Silkwood et al.
    Pages 159-181
  9. Kristina L. Go, Sooyeon Lee, Kevin E. Behrns, Jae-Sung Kim
    Pages 183-219
  10. Cheng Ji, Neil Kaplowitz, Hui Han
    Pages 221-250
  11. Wenke Feng, Craig McClain
    Pages 251-283
  12. Back Matter
    Pages 285-290

About this book


This essential volume presents comprehensive information on cell death and autophagy in liver diseases, including the role and molecular signaling pathways of cell death in alcohol and non-alcoholic fatty liver disease, bile acids, hepatitis C virus and drug-induced liver injury. The book starts with a discussion of lipotoxicity in non-parenchymal cells, followed by a discussion of cell death and autophagy in cholangiocytes, hepatic stellate cells and Kupffer cells in hepatic biliary diseases, fibrosis and liver inflammation. The book also covers Bcl-2 family proteins, beta-catenin and HMGB1 signaling in regulating cell death in the liver as well as mitochondria, ER stress and gut microbiota on liver injury. The Cell Death in Biology and Diseases series has recruited world experts ranging from basic scientists to clinicians on cell death in liver diseases. Likewise the contributors of this volume are leaders in their fields with worldwide expertise and perspective. Molecules, Systems and Signaling in Liver Injury is an essential companion to Hepatocytes and Non-Parenchymal Cells and Diseases. It is beneficial for both clinicians and basic scientists and is relevant to those working on drug discovery for preventing and treating liver diseases by targeting cell death and autophagy pathways.


mitophagy liver inflammation oncogenesis apoptosis liver cancer

Editors and affiliations

  • Wen-Xing Ding
    • 1
  • Xiao-Ming Yin
    • 2
  1. 1.Department of Pharmacology Toxicology and TherapyThe University of Kansas Medical CenterKansas CityUSA
  2. 2.Health Pathology LaboratoryIndiana UniversityIndianapolisUSA

About the editors

Dr. Wen-Xing Ding is an Associate Professor of Department of Pharmacology, Toxicology and Therapeutics at The University of Kansas Medical Center. He received his Ph.D. from the National University of Singapore. He did his Postdoctoral training at University of Pittsburgh. In the past decade, Dr. Ding’s research has been focused on the molecular mechanisms of cell death and autophagy in alcohol and drug-induced liver injury as well as liver tumorigenesis. Dr. Ding is a member of American Association of Studies of Liver Disease (AASLD), Society of Toxicology (SOT) and Research society of Alcoholism. Dr. Ding was a Liver Scholar of American Liver Foundation and a recipient of University Scholarly Achievement Award. Dr. Ding has published more than 100 papers in peer-reviewed journals and his research work is currently supported by NIAAA and NIDDK.

Dr. Xiao-Ming Yin is the Louis Y. Mazzini Professor of Pathology at the Department of Pathology and Laboratory Medicine,

Indiana University School of Medicine.  He obtained his medical degree from Shanghai Medical University and his PhD degree from University of Texas Southwestern Medical Center at Dallas.  He completed his post-doctoral fellow training and his pathology residency training at Washington University in St. Louis. Dr. Yin is a member of several scientific societies and is a fellow of American Association of Studies of Liver Disease (AASLD). He has won the Outstanding Investigator Award from American Society for Investigative Pathology (ASIP). His research interest is the cell death and survival in tissue injury and cancer biology, particularly in the liver system.  

Bibliographic information