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© 2017

Perioperative Inflammation as Triggering Origin of Metastasis Development

  • Michael W. Retsky
  • Romano Demicheli

Benefits

  • Will thoroughly explain previously unconnected clinical date such as why mammography works better for women age 50-59 than for women age 40-49;

  • Will explore why adjuvant chemotherapy works best for premenopausal patients with positive lymph nodes and may also explain the racial disparity in outcome;

  • Focuses on post-operative inflammation and its role in metastatic relapse.

Book

Table of contents

  1. Front Matter
    Pages i-xxiii
  2. Michael Baum
    Pages 1-18
  3. Michael W. Retsky, Romano Demicheli
    Pages 19-53
  4. Georgios K. Georgiou, Evangelos Briasoulis
    Pages 55-81
  5. Mazen A. Juratli, Dmitry A. Nedosekin, Mustafa Sarimollaoglu, Eric R. Siegel, Ekaterina I. Galanzha, Vladimir P. Zharov
    Pages 109-122
  6. Osaro Erhabor, Frank Udomah, Yakubu Abdulrahaman, Isaac Zama, Momodu Imoru, Teddy Charles Adias et al.
    Pages 123-159
  7. Marie Louise Bønnelykke-Behrndtz, Henrik Schmidt, Yi Feng, Paul Martin
    Pages 183-199
  8. Patrice Forget, Marc De Kock
    Pages 201-208
  9. Romano Demicheli
    Pages 209-225

About this book

Introduction

The book will explain previously unconnected clinical data such as why mammography works better for women age 50-59 than it does for women age 40-49, why adjuvant chemotherapy works best for premenopausal patients with positive lymph nodes, and it may also explain the racial disparity in outcome. In particular, it points to the perioperative period when systemic inflammation persists for a week or so. This can lead to a variety of mechanisms whereby single cancer cells (perhaps from the marrow) begin division and angiogenesis of dormant avascular micrometastases occurs leading to early relapses.

With chapters presented from distinguished scientists and physicians in a variety of specialties that relate to and border the effects we present, this volume can be used as a reference for practicing physicians and as a jumping-off point for researchers to explore new therapeutic opportunities.

Keywords

Inflammation Perioperative Inflammation Metastasis Mammography NSAID

Editors and affiliations

  • Michael W. Retsky
    • 1
  • Romano Demicheli
    • 2
  1. 1.Harvard TH Chan School of Public HealthBostonUSA
  2. 2.Istituto Nazionale Tumori di MilanoFondazione IRCCSMilanItaly

About the editors

Michael Retsky, PhD, is Research Associate, Harvard TH Chan School of Public Health and Honorary Faculty, University College London

Romano Demicheli, MD, PhD, is Senior Researcher, Istituto Nazionale Tumori di Milano

Bibliographic information

  • Book Title Perioperative Inflammation as Triggering Origin of Metastasis Development
  • Editors Michael W. Retsky
    Romano Demicheli
  • DOI https://doi.org/10.1007/978-3-319-57943-6
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-57942-9
  • Softcover ISBN 978-3-319-86289-7
  • eBook ISBN 978-3-319-57943-6
  • Edition Number 1
  • Number of Pages XXIII, 236
  • Number of Illustrations 10 b/w illustrations, 39 illustrations in colour
  • Topics Cancer Research
  • Buy this book on publisher's site
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