Perioperative Inflammation as Triggering Origin of Metastasis Development

  • Michael W. Retsky
  • Romano Demicheli

Table of contents

  1. Front Matter
    Pages i-xxiii
  2. Michael Baum
    Pages 1-18
  3. Michael W. Retsky, Romano Demicheli
    Pages 19-53
  4. Georgios K. Georgiou, Evangelos Briasoulis
    Pages 55-81
  5. Mazen A. Juratli, Dmitry A. Nedosekin, Mustafa Sarimollaoglu, Eric R. Siegel, Ekaterina I. Galanzha, Vladimir P. Zharov
    Pages 109-122
  6. Osaro Erhabor, Frank Udomah, Yakubu Abdulrahaman, Isaac Zama, Momodu Imoru, Teddy Charles Adias et al.
    Pages 123-159
  7. Marie Louise Bønnelykke-Behrndtz, Henrik Schmidt, Yi Feng, Paul Martin
    Pages 183-199
  8. Patrice Forget, Marc De Kock
    Pages 201-208
  9. Romano Demicheli
    Pages 209-225

About this book


The book will explain previously unconnected clinical data such as why mammography works better for women age 50-59 than it does for women age 40-49, why adjuvant chemotherapy works best for premenopausal patients with positive lymph nodes, and it may also explain the racial disparity in outcome. In particular, it points to the perioperative period when systemic inflammation persists for a week or so. This can lead to a variety of mechanisms whereby single cancer cells (perhaps from the marrow) begin division and angiogenesis of dormant avascular micrometastases occurs leading to early relapses.

With chapters presented from distinguished scientists and physicians in a variety of specialties that relate to and border the effects we present, this volume can be used as a reference for practicing physicians and as a jumping-off point for researchers to explore new therapeutic opportunities.


Inflammation Perioperative Inflammation Metastasis Mammography NSAID

Editors and affiliations

  • Michael W. Retsky
    • 1
  • Romano Demicheli
    • 2
  1. 1.Harvard TH Chan School of Public HealthBostonUSA
  2. 2.Istituto Nazionale Tumori di MilanoFondazione IRCCSMilanItaly

Bibliographic information

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