© 2017

Store-Operated Ca²⁺ Entry (SOCE) Pathways

Emerging Signaling Concepts in Human (Patho)physiology

  • Klaus Groschner
  • Wolfgang F. Graier
  • Christoph Romanin
  • Describes the role of SOCE pathways in health and disease

  • Combines basic research with clinical aspects

  • The second edition was updated with new discoveries in the field of structural biology, optogenetics and disease

  • Introduces the most recent concepts of linkage between SOCE and mitochondrial Ca2+ signaling

  • Gives insight into the newly identified molecular structure of the STIM-Orai machinery at the atomic resolution level


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 993)

Table of contents

  1. Front Matter
    Pages i-xxix
  2. SOCE: Fundamental Mechanistic Concepts

    1. Front Matter
      Pages 1-1
    2. James W. Putney
      Pages 3-13
    3. Jinhui Zhu, Qingping Feng, Peter B. Stathopulos
      Pages 15-38
    4. Marc Fahrner, Rainer Schindl, Martin Muik, Isabella Derler, Christoph Romanin
      Pages 59-81
    5. Robert M. Nwokonko, Xiangyu Cai, Natalia A. Loktionova, Youjun Wang, Yandong Zhou, Donald L. Gill
      Pages 83-98
    6. Guolin Ma, Shufan Wen, Yun Huang, Yubin Zhou
      Pages 117-138
    7. Dora Bodnar, Woo Young Chung, Dongki Yang, Jeong Hee Hong, Archana Jha, Shmuel Muallem
      Pages 139-157
  3. SOCE: Crosstalk Between Organelle and Cellular Compartments

About this book


This second edition of the book on Store-operated Ca2+  Entry Pathways has been updated with the newest discoveries that emerged in the field within the last five years. The crystal structure of the Ca2+ signaling core complex is described which adds to a new understanding of the molecular interactions involved. Each chapter has been revised and extended. The book retains its interdisciplinary approach and supplies biochemists, cell biologists and biophysicists as well as clinicians in immunology, neurology and cardiology with valuable information on Ca2+ signaling mechanisms, functions, dysfunctions and their consequences.


Calcium Signaling STIM-Orai Pathway TRP Pathways Crystal Structure Core Complex Calcium Entry Pathways

Editors and affiliations

  • Klaus Groschner
    • 1
  • Wolfgang F. Graier
    • 2
  • Christoph Romanin
    • 3
  1. 1.Institute of BiophysicsMedical University of GrazGrazAustria
  2. 2.Institute of Molecular Biology and BiochemistryMedical University of GrazGrazAustria
  3. 3.Institute of BiophysicsJohannes Kepler University LinzLinzAustria

About the editors

Prof. Klaus Groschner studied Pharmacy at the School of Pharmacy, University of Graz, Austria. He completed his PhD studies at the Department of Pharmacodynamics in Graz and received part of his postdoctoral education at the University of Miami, Florida, USA, studying electrophysiology and cell biology. In 1990 he became an Assistant Professor at the Department of Pharmacology and Toxicology and received his Habilitation in Pharmacology and Toxicology along with promotion to Associate Professor in 1993. Until 2011 he was head of a research unit for Physiology and Pharmacology of Membrane Transport at the Institute of Pharmaceutical Sciences at the University of Graz. Since 2012 he is Full Professor for Biophysics and Chairman at the Institute of Biophysics at the Medical University of Graz.

Prof. Wolfgang F. Graier studied Pharmacy at the University of Graz, Austria and received his PhD in Pharmacology at the Department of Pharmacology and Toxicology, University of Graz. In 1993, 1994 he was a postdoctoral research fellow, analyzing physiology and membrane biophysics at the Dalton Cardiovascular Research Center, University of Missouri, Columbia, USA. In 1994 he became an Assistant Professor at the Department of Medical Biochemistry, University of Graz. In 1995 he became Associate Professor (Habilitation) in Biochemical Pharmacology and in Physiology in 2001 at the Department of Medical Biochemistry, University of Graz. Since 2009 he is Full Professor for Molecular Biology and Chairman of the Institute of Molecular Biology and Biochemistry at the Medical University of Graz. Since 2015 he is also Head of the Nikon-Center of Excellence for Super-Resolution Microscopy: Cells & Organelles that is part of BioTechMed, the concerted research platform of the Medical University Graz, the University of Graz, and the Graz Technical University. In 2016 he co-founded a spin-off company named Next Generation Fluorescence Imaging, NGFI, (

 Prof. Christoph Romanin studied Chemistry at the Technical University of Graz, Austria and completed his doctoral studies at the Department of Pharmacology and Toxicology, University of Graz. In 1986 he started with a post-doc position at the Institute of Biophysics of the University of Linz, Austria, where he became Professor in Biophysics (Habilitation) in 1993 and served as an Associate Professor since 1997. In 2001 he was a guest researcher at the NIA, the National Institute on Aging of the NIH in Bethesda, USA. Currently, he is vice-chairman of the institute and head of the Ion Channel Group at the Institute of Biophysics in Linz, Austria.

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