Decoding Neural Circuit Structure and Function

Cellular Dissection Using Genetic Model Organisms

  • Arzu Çelik
  • Mathias F. Wernet

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Anatomy: High-Resolution Neuroanatomy Using Molecular-Genetic Tools

    1. Front Matter
      Pages 1-1
    2. Daryl M. Gohl, Javier Morante, Koen J.T. Venken
      Pages 3-39
    3. Kevin L. Briggman
      Pages 41-62
    4. Kazunori Shinomiya, Masayoshi Ito
      Pages 63-89
    5. Kazunari Miyamichi, Lindsay A. Schwarz
      Pages 91-148
    6. Mehmet Neset Özel, Peter Robin Hiesinger
      Pages 149-167
  3. Behavior: The Behavioral Contributions of Identified Cell Types

    1. Front Matter
      Pages 169-169
    2. Ibrahim Tastekin, Matthieu Louis
      Pages 171-189
    3. Stefanie Hampel, Andrew M. Seeds
      Pages 191-222
    4. Chiara Cianciolo Cosentino, Stephan C. F. Neuhauss
      Pages 223-239
    5. Terufumi Fujiwara, Eugenia Chiappe
      Pages 261-281
  4. Physiology: Visualizing the Activity of Identified Circuit Elements

    1. Front Matter
      Pages 307-307
    2. Thomas Riemensperger, Florian Bilz, André Fiala
      Pages 309-319
    3. Andreas M. Kist, Laura D. Knogler, Daniil A. Markov, Tugce Yildizoglu, Ruben Portugues
      Pages 321-341
  5. Development: The Molecular Determinants of Cell Type Diversity

  6. Epilogue: Future Outlook and Challenges in the Field of Circuit Science

    1. Front Matter
      Pages 507-507
    2. Ian A. Meinertzhagen
      Pages 509-518

About this book


This book offers representative examples from fly and mouse models to illustrate the ongoing success of the synergistic, state-of-the-art strategy, focusing on the ways it enhances our understanding of sensory processing. The authors focus on sensory systems (vision, olfaction), which are particularly powerful models for probing the development, connectivity, and function of neural circuits, to answer this question: How do individual nerve cells functionally cooperate to guide behavioral responses? Two genetically tractable species, mice and flies, together significantly further our understanding of these processes.

Current efforts focus on integrating knowledge gained from three interrelated fields of research: (1) understanding how the fates of different cell types are specified during development, (2) revealing the synaptic connections between identified cell types (“connectomics”) using high-resolution three-dimensional circuit anatomy, and (3) causal testing of how iden

tified circuit elements contribute to visual perception and behavior.


Neural circuitry Bbehavior Function Genetic dissection In vivo-imaging

Editors and affiliations

  • Arzu Çelik
    • 1
  • Mathias F. Wernet
    • 2
  1. 1.Department of Molecular Biology and GeneticsBoğaziçi UniversityBebekTurkey
  2. 2.Fachbereich Biologie, Chemie, Pharmazie, Institut für Biologie—NeurobiologieFreie Universität BerlinBerlinGermany

Bibliographic information

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