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© 2017

Cell Division Machinery and Disease

  • Monica Gotta
  • Patrick Meraldi
  • Reviews the current knowledge to critically evaluate the causal link between cell division machinery and disease

  • Identifies key open questions in the field and means for exploring them

  • Explores cell division and links to common disorders including cancer, aging and infertility

Book

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1002)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Warif El Yakoubi, Katja Wassmann
    Pages 1-17
  3. Maddalena Nano, Renata Basto
    Pages 19-45
  4. Alexander D. Rhys, Susana A. Godinho
    Pages 47-67
  5. Bas de Wolf, Geert J. P. L. Kops
    Pages 69-91
  6. Luca Cirillo, Monica Gotta, Patrick Meraldi
    Pages 93-124
  7. Anna-Maria Olziersky, S. Intidhar Labidi-Galy
    Pages 125-152
  8. Joana Catarina Macedo, Sara Vaz, Elsa Logarinho
    Pages 153-188
  9. Michael Polymenis, Brian K. Kennedy
    Pages 189-208
  10. Back Matter
    Pages 227-235

About this book

Introduction

This book critically evaluates the causal link between cell division machinery and disease. Further, it identifies key open questions in the field and the means for exploring them. Throughout the various chapters, internationally known contributors present the evidence for and against a causal link between key elements of the cell division machinery and diseases such as cancer, neuropathologies, aging, and infertility. A more clinically oriented chapter further discusses the current and future applications of anti-mitotic drugs in these diseases. Cell Division Machinery and Disease is essential reading for graduate or advanced graduate students, researchers or scientists working on cell division as well as clinicians interested in the molecular mechanisms of the discussed diseases.

Keywords

Centrosomes Infertility Mitosis Neuropathology Polycystic Kidney Disease

Editors and affiliations

  • Monica Gotta
    • 1
  • Patrick Meraldi
    • 2
  1. 1.Department of Cell Physiology and MetabolismFaculty of Medicine, Geneva UniversityGenevaSwitzerland
  2. 2.Department of Cell Physiology and MetabolismFaculty of Medicine, Geneva UniversityGenevaSwitzerland

About the editors

Monica Gotta is Ordinary Professor at the Medical Faculty of the University of Geneva. She has previously worked as a Swiss-National Science Foundation Professor at the ETH Zurich. Her research interests are the (a)symmetric cell divisions of C. elegans embryos and human cells. She has published 43 papers and 1 book chapter. She has also been awarded an EMBO YIP award.

Patrick Meraldi is Associate Professor at the Medical Faculty of the University of Geneva. He has previously worked as a Swiss-National Science Foundation Professor at the ETH Zurich. His research interest is primarily in the field of chromosome segregation in human cells. He has published 49 papers and 2 book chapters. He has also been awarded an EURYI award , an EMBO YIP award and the Walther Flemming Medal. 

Bibliographic information

  • Book Title Cell Division Machinery and Disease
  • Editors Monica Gotta
    Patrick Meraldi
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI https://doi.org/10.1007/978-3-319-57127-0
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-57125-6
  • Softcover ISBN 978-3-319-86083-1
  • eBook ISBN 978-3-319-57127-0
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages XIV, 235
  • Number of Illustrations 1 b/w illustrations, 32 illustrations in colour
  • Topics Cell Cycle Analysis
    Cell Physiology
    Cancer Research
  • Buy this book on publisher's site